The human endometrium is an extremely sensitive target for steroid hormones. During the menstrual cycle, this tissue undergoes dynamic changes which are reflected on the surface morphology of the epithelium, and which can be followed by scanning electron microscopy. The morphological changes peak at the midsecretory phase, with the formation of the so-called pinopodes. Increasing evidence suggests that these pinopodes are accurate markers for endometrial receptivity, and their detection may be of high clinical utility for the preparation of endometrium before embryo transfer.
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- PFOS is a chemical frequently used in industries that can enter the environment and is resistant to breakdown, leading to health concerns.
- Recent studies show a link between PFOS exposure in humans and various diseases, highlighting its impact on human health.
- Research indicates that PFOS negatively affects endometrial cell function and morphology, potentially leading to issues with embryo implantation due to mitochondrial damage and alterations in key protein expression.
Immunohistochemical examination of PNAd, α4β1 integrin and MUC-2 expressions in the secretary phase endometrium of women diagnosed with recurrent implantation failure.
J Reprod Immunol
February 2025
Department of Histology and Embryology, Medical School, University of Cukurova, Adana, Turkiye.
Objective: Successful embryo implantation is contingent upon the intricate interaction between the endometrium and the blastocyst. Recurrent implantation failure (RIF) signifies the clinical challenge of failing pregnancy post-transfer of high-quality embryos, fresh or frozen, in at least three in vitro fertilization (IVF) cycles, often in women under 40 years. Recent studies identify impaired blastocyst maternal tissue communication among recurrent implantation failure causes.
View Article and Find Full Text PDFMelatonin improves endometrial receptivity and embryo implantation via MT2/PI3K/LIF signaling pathway in sows.
J Anim Sci Biotechnol
January 2025
Key Laboratory of Northwest China's Pig Breading and Reproduction, Ministry of Agriculture and Rural Affairs of the People's Republic of China, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Background: Increased backfat thickness of sows in early gestation is negative to reproductive performance. Endometrial receptivity is an important determinant of reproductive success, but it is unclear whether the effect of sow backfat thickness on litter size is associated with endometrial receptivity and whether melatonin treatment may have benefits. The present study seeks to answer these questions through in vitro and in vivo investigations.
View Article and Find Full Text PDFUnlabelled: Currently, chronic salpingo-oophoritis (CS) is still an urgent problem in the statistics of diseases of the female genital organs. In 35% of women, its course leads to disorder of the fallopian tubes patency and infertility. An additional indirect mechanism of infertility can be the morpho-functional failure of the endometrium.
View Article and Find Full Text PDFMicroRNAs, endometrial receptivity and molecular pathways.
Reprod Biol Endocrinol
November 2024
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
MicroRNAs (miRNAs) are a type of specific molecules that control the activities of the uterus, such as the process of cellular maturing and evolution. A lot of substances like growth factors, cytokines, and transcription factors play a role in embryo-endometrial interaction. MiRNAs could regulate various these factors by attaching to the 3' UTR of their mRNAs.
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