Epidemiological data indicate that exposure to metal and metalloid species, including arsenic(III), chromium(VI), and nickel(II), increases the risk of cancer, particularly of the lung and skin. Alterations in normal signal transduction as a result of exposure to carcinogenic metals, and to metal-catalyzed reactive oxygen species (ROS) formation, appear to play an important role in the etiology of metal-induced carcinogenesis. Signaling components affected by metals include growth factor receptors, G-proteins, MAP kinases, and nuclear transcription factors. This article reviews current literature on the effects of carcinogenic metals and metal-induced ROS on cancer-related signaling pathways. In addition, the mechanisms by which those changes occur, and the role of those changes in carcinogenesis are discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mrfmmm.2003.08.025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Heavy metal(loid)s and nutrients in sewage sludge in Portugal - Suitability for use in agricultural soils and assessment of potential risks.
Sci Total Environ
January 2025
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. Electronic address:
The presence of heavy metal(loid)s in sewage sludge is a cause of concern and an obstacle to its agricultural valorisation. This study analysed the elemental composition of sewage sludge from 42 Portuguese wastewater treatment plants (WWTPs) during summer and winter, investigating heavy metal(loid) contamination, nutrient content, and potential risks related to sludge application to agricultural soils. Levels of 8 heavy metal(loid)s were investigated, ranging from not detected (Hg) to 5120 mg kg dw (Zn), decreasing in the order Zn > Cu > Cr > Ni > Pb > As>Cd > Hg.
View Article and Find Full Text PDFCompact Disc-Derived Nanocarbon-Supported Catalysts with Extreme Catalytic Activity.
ACS Appl Mater Interfaces
January 2025
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Advanced carbon-metal hybrid materials with controllable electronic and optical properties, as well as chemical reactivities, have attracted significant attention for emerging applications, including energy conversion and storage, catalysis and environmental protection. However, the commercialization of these materials is hampered by several vital problems, including energy-intensive synthesis and expensive chemicals, and inefficient control of their structures and properties. Herein, we report the simple and controllable engineering of nanocarbon-metal self-assembled silver nanocatalysts (SSNs) derived from polycarbonate (PC)-based optical discs using microplasmas under ambient conditions.
View Article and Find Full Text PDFGeochemical fractionation and bioavailability of heavy metals in the middle gangetic plain: Assessing ecological risks in water and sediment systems.
Sci Total Environ
January 2025
School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India. Electronic address:
The Gangetic Plain, one of the world's most fertile regions, is vital to food and water security in densely populated areas. However, metal contamination in sediments and water poses significant challenges, owing to intensified industrial and agricultural activities and periodic flooding. The ecological risks imposed by metals in the Middle Gangetic Plain remain underexplored because of limited data on their bioavailability across varying sediment depths.
View Article and Find Full Text PDFResearch on the effect of eco-friendly additives on selected parameters and microbial decomposition of marine diesel oil (MDO).
Sci Rep
January 2025
Faculty of Marine Engineering, Gdynia Maritime University, Morska 81-87, 81-225, Gdynia, Poland.
This paper presents the effect of environmentally friendly additives on selected parameters and microbial degradation of Marine Diesel Oil (MDO). Microbiological contamination is a serious problem in MDO and other petroleum products. For this reason, it was decided to investigate the effects of environmentally friendly additives such as silver solution and colloidal nanosilver, as well as effective liquid microorganisms and ceramic tubes with different percentages of them in diesel oil (MDO) on its selected parameters and inhibition of bacterial and fungal growth.
View Article and Find Full Text PDFThe effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment.
Sci Rep
January 2025
Department of Environmental Health Engineering, Khalkhal University of Medical Sciences, Khalkhal, Iran.
Heavy metals (HMs) may cause the generation of reactive oxygen species (ROS), which results in oxidative stress and eventually leads to an increase in cardiovascular diseases (CVD). The Hoveyzeh Cohort Study Center provided clinical data for cardiovascular cases. The collection of samples was done randomly.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!