Conicamin, a novel histamine antagonist from the mediterranean tunicate Aplidium conicum.

Bioorg Med Chem Lett

Dipartimento di Chimica delle Sostanze Naturali, via D. Montesano, 49, I-80131 Napoli, Italy.

Published: December 2003

In addition to the known 6-bromo-hypaphorine (2) and plakohypaphorine-A (3), the methanol extract of the Mediterranean tunicate Aplidium conicum was shown to contain conicamin, a novel indole alkaloid having histamine-antagonistic activity which structure was determined to be 1 on the basis of the spectral data.

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http://dx.doi.org/10.1016/j.bmcl.2003.08.081DOI Listing

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