DAPI derivative: a fluorescent DNA dye that can be covalently attached to biomolecules.

Bioorg Med Chem Lett

Roche Diagnostics Corporation, 9115 Hague Road, Indianapolis, IN 46250, USA.

Published: December 2003

The preparation of a DAPI (4',6-diamidino-2-phenylindole) derivative is described. The resulting derivative retains the fluorogenic property upon binding to double-stranded DNA. Its ability for bioconjugation through amide linkage is demonstrated.

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http://dx.doi.org/10.1016/j.bmcl.2003.09.038DOI Listing

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