Interferon (IFN) therapy allows the eradication of hepatitis C virus (HCV) in some part of patients with chronic hepatitis C which is major cause of hepatocellular carcinoma (HCC). To clarify characteristics and prognoses of HCC detected in these patients (sustained responders to IFN), we compared HCC in sustained responders with HCC detected in patients without a sustained response (non-sustained responders). Characteristics and prognoses were compared in nine cases of HCC detected in sustained responders after IFN therapy and 61 cases of HCC detected in non-sustained responders at one of five our institutions. HCC in sustained responders often were larger (P=0.0051), less differentiated tumor (P=0.0084) than HCC in non-sustained responders when it was detected. No differences were observed in overall survival rate between sustained responders and non-sustained responders, but disease-free survival was higher in cases of HCC in sustained responders (P=0.0494). HCC detected in sustained responders often appear more advanced when detected than HCC in non-sustained responders, but recurrence seems to be less frequent when the initial HCC is treated sufficiently.
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http://dx.doi.org/10.1016/j.cdp.2003.09.007 | DOI Listing |
Sci Rep
December 2024
Faculty of Nursing, Chulalongkorn University, Borommaratchachonnani Srisataphat, Building, Rama 1 Road, Pathumwan, 10330, Bangkok, Thailand.
Frontline health workers face a significant issue concerning mental health, particularly stress and burnout. Nurses, being among them, grapple with this problem. The study aims to investigate the prevalence and determinants of burnout among nurses.
View Article and Find Full Text PDFLasers Surg Med
December 2024
Department of Dermatology, Veterans Health Administration, San Antonio, Texas, USA.
Objectives: Glomangiomas are benign vascular malformations that exist within the spectrum of glomuvenous malformations which consist of varying amounts of glomus cells, vascular spaces, and smooth muscle. Glomangiomas are often treated due to associated pain, particularly when located on pressure areas such as the back or extensor surfaces, which can cause difficulty with certain activities and occupational functions. Histologically glomangiomas consist of prominent dilated vascular spaces lined by glomus cells typically situated in the deep-dermis to subcutaneous fat which limits treatment to modalities capable of reaching the depth of the tumor including excision, sclerotherapy, and laser therapy.
View Article and Find Full Text PDFIJID Reg
March 2025
Programme for Research in Epidemic Preparedness and Response (PREPARE), Ministry of Health, Singapore.
The COVID-19 pandemic highlighted the critical need for well-established clinical research networks capable of rapid response during infectious disease outbreaks. In Southeast Asia, the absence of active research networks at the onset of the COVID-19 contributed to gaps in regional preparedness. This manuscript discusses the challenges and opportunities identified during a regional workshop held in Singapore (February 26 to March 1, 2024), which brought together 130 stakeholders from across the region.
View Article and Find Full Text PDFBMC Public Health
December 2024
Mersin City Education and Training Hospital, Clinic of Obstetrics and Gynecology, Korukent District 96015 St. Mersin Entegre Sağlık Kampüsü, Toroslar/Mersin, 33240, Türkiye.
Background: The influx of Syrian refugees since 2012 has introduced demographic changes in Türkiye that face significant barriers to healthcare, particularly for women's health and cervical cancer awareness. Studies indicate alarmingly low awareness, with only 4% of Syrian women aware of the smear test.
Objective: This study examines cervical cancer awareness among Syrian refugee women in Türkiye and assesses the impact of sociocultural factors-education level, healthcare access, and language proficiency-on healthcare utilization.
Compr Rev Food Sci Food Saf
January 2025
Food Safety Department, Teagasc Food Research Centre, Ashtown, Dublin, Ireland.
Controlling Listeria monocytogenes and its associated biofilms in the food industry requires various disinfection techniques, including physical, chemical, and biological treatments. Biocides, owing to their ease of use, cost-effectiveness, dissolvability in water, and efficacy against a wide range of microorganisms, are frequently selected options. Nonetheless, concerns have been raised about their efficacy in controlling L.
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