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Endovascular Approaches to Diagnosing Pelvic Varicose Veins in Men: Investigating Efficacy and Outcomes.
Surg Technol Int
January 2025
Department of Psychiatry and Narcology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
Pelvic Venous Disorder (PEVD) and May-Thurner syndrome (MTS) represent relatively understudied vascular issues that can significantly impact patients' quality of life. This study aims to evaluate the efficacy of surgical treatment for PEVD and MTS, conduct a comparative analysis of outcomes, and determine the practical significance of different therapeutic approaches. The study was conducted from 2019 to 2022 in Moscow, Russia, encompassing two outpatient clinics.
View Article and Find Full Text PDFT-cell prolymphocytic leukemia (T-PLL) is an aggressive lymphoid malignancy with limited treatment options. To discover new treatment targets for T-PLL, we performed high-throughput drug sensitivity screening on 30 primary patient samples ex-vivo. After screening over 2'800 unique compounds, we found T-PLL to be more resistant to most drug classes, including chemotherapeutics, compared to other blood cancers.
View Article and Find Full Text PDFEffect evaluation of a participatory developed school-based healthy sleep intervention for adolescents.
Health Psychol
January 2025
Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University.
Objective: Sleep deprivation and reduced sleep quality are common in adolescents and negatively impact their physical and mental wellbeing. This study evaluates the effect of a participatory-developed school-based healthy sleep intervention for adolescents.
Method: A 16-week long intervention, cocreated with adolescents, was conducted with two schools with four schools serving as measurement-only controls.
The impact of depression and anxiety disorders on postoperative outcomes for patients having total hip or knee arthroplasty: Protocol of a meta-analytic study from cohort studies.
PLoS One
January 2025
Department of Anorectal Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Background And Purpose: Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are widely performed surgeries for end-stage joint disease, yet the influence of depression and anxiety on postoperative outcomes remains unclear. This study aims to consolidate current evidence on the relationship between preoperative depression and/or anxiety disorders and postoperative outcomes in adult patients undergoing primary THA or TKA. Given the potential for these psychiatric conditions to affect recovery, pain management, and overall satisfaction, the results of this study are crucial to inform targeted perioperative interventions and improve patient-centered care.
View Article and Find Full Text PDFTherapeutic drug monitoring versus Bayesian AUC-based dosing for vancomycin in routine practice: a cost-benefit analysis.
J Antimicrob Chemother
January 2025
Pharmacy Department, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Background: AUC-based dosing with validated Bayesian software is recommended as a good approach to guide bedside vancomycin dosing.
Objectives: To compare treatment and vancomycin-associated acute kidney injury (AKI) costs between Bayesian AUC-based dosing and conventional therapeutic drug monitoring (TDM) using steady-state plasma concentrations of vancomycin administered as continuous infusion in hospitalized non-critically ill patients with severe Gram-positive infection.
Methods: A cost-benefit analysis presented as a return on investment (ROI) analysis from a hospital perspective was conducted using a decision tree model (TDM versus AUC-based dosing) to simulate treatment cost (personnel, serum sampling and drug cost), vancomycin-associated AKI risk and cost up to 14 days.
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