Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein.
Fluids Barriers CNS
January 2025
Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven - University of Leuven, O&N II Herestraat 49 box 820, 3000, Leuven, Belgium.
Background: Therapeutic antibodies for the treatment of neurological disease show great potential, but their applications are rather limited due to limited brain exposure. The most well-studied approach to enhance brain influx of protein therapeutics, is receptor-mediated transcytosis (RMT) by targeting nutrient receptors to shuttle protein therapeutics over the blood-brain barrier (BBB) along with their endogenous cargos. While higher brain exposure is achieved with RMT, the timeframe is short due to rather fast brain clearance.
View Article and Find Full Text PDFAccurate malaria diagnosis with precise identification of Plasmodium species is crucial for an effective treatment. While microscopy is still the gold standard in malaria diagnosis, it relies heavily on trained personnel. Artificial intelligence (AI) advances, particularly convolutional neural networks (CNNs), have significantly improved diagnostic capabilities and accuracy by enabling the automated analysis of medical images.
View Article and Find Full Text PDFA comparative analysis of collagen based dressings and polysaccharide microspheres for hemostasis management in hepatic stab wounds.
Sci Rep
January 2025
General and Digestive Unit, Central Hospital of Defense, Spanish-Ministry of Defense, Glorieta del Ejército, 1, 28047, Madrid, Spain.
This study aims to evaluate two of the most commonly used products, the collagen-based patch (Hemopatch) and the micropolysaccharide microspheres powder (Perclot), in the context of stab liver injury in pigs. The objectives of this study were to assess blood loss at various time intervals up to 24 h, survival rates, and mean arterial pressure. The research involved 18 Large-White swine.
View Article and Find Full Text PDFAssociation Between Daily Insulin Dose Adjustments and Glycemic Control in Non-Critically Ill Hospitalized Hyperglycemic Patients: A Retrospective Cohort Study.
Endocr Pract
January 2025
Division of Endocrinology, Diabetes, & Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:
Objective: To evaluate the efficacy of daily insulin dose increases in managing inpatient hyperglycemia.
Methods: Retrospective study of patients discharged from two urban academic medical centers and three large suburban community hospitals between 2015 and 2019 who received ≥10 units of basal insulin on any day. On hyperglycemic days (mean glucose ≥180 mg/dL), we categorized the relative insulin dose increases into four categories based on percentage changes from the previous day.
Feasibility of rabbit auricular VX2 tumor model as an experimental model for intra-arterial embolization.
PLoS One
January 2025
Department of Radiology, Chung-Ang University Gwangmyeong Hospital, Seoul, Republic of Korea.
This study aimed to evaluate the feasibility of VX2 tumor in rabbit auricles as an experimental model for intra-arterial embolization. This study was approved by our Institutional Animal Care and Use Committee. VX2 tumors were implanted in both auricles of 12 New Zealand White Rabbits.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!