Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of 35 to 124 min after administration of the preoperative dose, except in bone specimens, where they reached 3.9 +/- 2.0 mg/liter.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC296177 | PMC |
| http://dx.doi.org/10.1128/AAC.47.12.3964-3966.2003 | DOI Listing |
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