Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1590/s1413-86702003000600001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Electrocardiographic abnormalities are associated with seropositive Trypanosoma cruzi infection status using a simplified cardiac diagnostic evaluation in dogs.
J Am Vet Med Assoc
August 2024
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX.
Article Synopsis
- - This study aimed to analyze the relationship between heart problems and Trypanosoma cruzi serostatus in dogs by using a straightforward diagnostic process involving blood tests, ECGs, and echocardiograms in 46 dogs at high risk for infection.
- - The results showed that 19 dogs tested positive for T. cruzi antibodies, with some exhibiting heart issues like conduction abnormalities and echocardiographic changes, particularly myxomatous mitral valve disease (MMVD); older seropositive dogs were more likely to have these conditions.
- - The research concluded that while echocardiographic abnormalities alone didn’t help in determining seropositivity, simple tests like ECGs and cardiac troponin I assessments are effective
[Takotsubo syndrome in dengue patient].
Medicina (B Aires)
June 2024
Departamento de Terapia Intensiva-DAIPIC, Hospital de Infecciosas Francisco J. Muñiz, Buenos Aires, Argentina.
Takotsubo syndrome, was described in Japan in 1990, it is a stress cardiomyopathy, predominantly in women, usually postmenopausal. Cardiac hypokinesia occurs, with involvement of multiple coronary territories. In intensive care unit (ICU), it is considered underdiagnosed.
View Article and Find Full Text PDFThe mitochondrial uncoupler 2,4-dinitrophenol modulates inflammatory and oxidative responses in Trypanosoma cruzi-induced acute myocarditis in mice.
Cardiovasc Pathol
August 2024
Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Alfenas, Alfenas, 37130-001, Minas Gerais, Brazil; Programa de Pós-Graduação em Biociências Aplicadas à Saúde, Universidade Federal de Alfenas, Alfenas, 37130-001, Minas Gerais, Brazil; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, 37130-001, Minas Gerais, Brazil; Departamento de Biologia Animal, Programa de Pós-Graduação em Biologia Animal, Universidade Federal de Viçosa, Viçosa, 36570-900, Minas Gerais, Brazil. Electronic address:
By uncoupling oxidative phosphorylation, 2,4-dinitrophenol (DNP) attenuates reactive oxygen species (ROS) biosynthesis, which are known to aggravate infectious myocarditis in Chagas disease. Thus, the impact of DNP-based chemotherapy on Trypanosoma cruzi-induced acute myocarditis was investigated. C56BL/6 mice uninfected and infected untreated and treated daily with 100 mg/kg benznidazole (Bz, reference drug), 5 and 10 mg/kg DNP by gavage for 11 days after confirmation of T.
View Article and Find Full Text PDFPositive clinical outcome using a modified dosing regimen of benznidazole in dogs at high risk for infection or acutely infected with Trypanosoma cruzi.
J Vet Intern Med
May 2024
Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Trypanosoma cruzi infection in dogs can cause heart failure and sudden death with few treatment options available. A litter of 4 dogs living in a T cruzi endemic area were randomized to prophylaxis and nonprophylaxis groups as part of a study evaluating a modified benznidazole dosing regimen administered twice weekly to prevent T cruzi infection during a vector transmission season. The 2 dogs that received prophylaxis remained healthy without T cruzi infection or cardiac disease for >2 years.
View Article and Find Full Text PDFAssessment of biomarkers and clinical parameters as predictors of survival in patients with chagasic heart failure.
PLoS Negl Trop Dis
December 2023
Laboratory of Medical Investigation in Immunology (LIM-48), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Background: Chagas disease, endemic in Latin America and spreading globally due to emigration, has a significant health burden, particularly in relation to chagasic heart failure (HF). Chagasic cardiomyopathy (CCM) is characterized by chronic inflammatory myocardial disease. This study aimed to identify inflammatory parameters and biomarkers that could aid in the management of patients with chagasic HF.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!