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Antarctic Expeditions: A Systematic Review of the Physiological, Nutritional, Body Composition and Psychological Responses to Treks Across the Continental Ice.
Sports Med
December 2024
Ultra Sports Science Foundation, Pierre-Bénite, France.
Background: Antarctic expeditions, although supported by scientific knowledge, face various challenges, with little research conducted to explore the physical demands that explorers experience.
Objective: To summarise physiological, psychological, body composition and nutritional changes faced during trek expeditions in the Antarctic's continental portion.
Design: Systematic review.
Brassica rapa L. polysaccharide mitigates hypobaric hypoxia-induced oxidation and intestinal damage via microbiome modulation.
NPJ Sci Food
December 2024
School of Public Health, Lanzhou University, Lanzhou, 730000, China.
The high-altitude, low-pressure, and hypoxia environment poses a significant threat to human health, particularly causing intestinal damage and disrupting gut microbiota. This study investigates the protective effects of Brassica rapa L. crude polysaccharides (BRP) on intestinal damage in mice exposed to hypobaric hypoxic conditions.
View Article and Find Full Text PDFChronic intermittent hypobaric hypoxia alleviates early-stage posttraumatic osteoarthritis via NF-κB/Nrf2 pathway in mice.
J Orthop Surg Res
December 2024
Department of Orthopaedic Trauma, Hebei Medical University Third Hospital, Ziqiang Road No.139, Shijiazhuang, Hebei Province, 050051, China.
Background: Posttraumatic osteoarthritis (PTOA) is directly associated with early acute articular cartilage injury. Inhibition of cartilage destruction immediately following joint damage can effectively slow or prevent PTOA progression. Therefore, we sought to determine intervention targets and therapeutic strategies in the acute stage of cartilage injury.
View Article and Find Full Text PDFEffect of age on lung adaptation to high-altitude hypoxia in Tibetan sheep.
Front Vet Sci
December 2024
Gansu Key Laboratory of Herbivorous Animal Biotechnology, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
After prolonged adaptation to high-altitude environments, Tibetan sheep have developed a robust capacity to withstand hypobaric hypoxia. Compared to low-altitude sheep, various organs and tissues in Tibetan sheep have undergone significant adaptive remodeling, particularly in the lungs. However, whether lambs and adult Tibetan sheep exhibit similar adaptations to high-altitude hypoxia remains unclear.
View Article and Find Full Text PDFA stable rat model of high altitude pulmonary edema established by hypobaric hypoxia combined diurnal temperature fluctuation and exercise.
Biochem Biophys Res Commun
December 2024
Department of Pharmacy, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, 730050, People's Republic of China; Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China. Electronic address:
Hypobaric hypoxia (HH) is regarded as the main cause of high-altitude pulmonary edema (HAPE), however, the effect of diurnal temperature fluctuation and exercise has been overlooked. The aim of current study was to elucidate the role of diurnal temperature fluctuation and exercise in the development of HAPE and establish a reliable experimental rat model. Male SPF Wistar rats were assigned to control group (1400 m, 25 °C) and five model groups: Model Ⅰ group (6000 m, 25 °C), Model Ⅱ group (6000 m, 2 °C), Model Ⅲ group (6000 m, 12 °C/2 °C light/dark cycle), Model IV group (6000 m, 2 °C, and exercise) and Model V group (6000 m, 12 °C/2 °C light/dark cycle, and exercise).
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