On the complexity of fundamental computational problems in pedigree analysis.

J Comput Biol

Computer Science Department, University of California, Davis 95616, USA.

Published: June 2004

Pedigree analysis is a central component of many current efforts to locate genes that contribute to diseases or to valuable traits. The analysis usually involves solving one of two very computation-intense problems. We analyze the complexity of these two problems. Surprisingly, we show that both problems are NP-hard even for pedigrees that contain no inbreeding loops.

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http://dx.doi.org/10.1089/106652703322539088DOI Listing

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