AI Article Synopsis
- The study examined how 5-hydroxytryptamine (5-HT) influences amylase secretion in rat parotid glands under different thyroid conditions: intact control, hypothyroid (after thyroidectomy), and hyperthyroid (following treatment with sodium l-triiodothyronine).
- Hyperthyroid rats had higher baseline amylase release, and when stimulated with 5-HT, amylase release was lower in hypothyroid rats and higher in hyperthyroid rats compared to controls.
- The effects of 5-HT on amylase secretion were partly blocked by certain receptor antagonists, indicating that serotoninergic receptors play a key role, and thyroid status affects how 5-HT functions in this
Article Abstract
The effects of 5-hydroxytryptamine (5-HT) upon amylase secretion by rat parotid glands were studied in three groups of animals: (a) intact control rats (euthyroid rats); (b) hypothyroid rats obtained by surgical thyroidectomy 2 wk before the experiments; and (c) hyperthyroid rats obtained by the administration of sodium l-triiodothyronine for 2 wk before the experiments. Hyperthyroid rats showed significantly higher baseline amylase release than control rats. When the glands were stimulated with 5-HT (30 micro m), amylase release was significantly lower in the hypothyroid group and higher in the hyperthyroid rats than in control group. Addition of cholinergic, adrenergic or substance P antagonists did not modify 5-HT-stimulated amylase activity. The effects of 5-HT were partly but significantly blocked by the addition of 10 micro m methysergide (HT1/2/7 receptor blocker) in the three groups of rats. In contrast, 10 micro m ketanserine (HT2A receptor blocker) partly blocked the response to 5-HT only in the hyperthyroid animals. It was concluded that 5-HT induces amylase secretion by rat parotid glands through specific serotoninergic receptors, and that thyroid status modulates the 5-HT effect.
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| http://dx.doi.org/10.1111/j.0909-8836.2003.00087.x | DOI Listing |
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