Disturbances in autonomic nervous system function have been studied during clofelin poisoning in children. A correlation has been established between changes in autonomic homeostasis and reduction in body temperature, bradycardia and arterial hypotension. The studies of cortisol blood level suggests two phases of poisoning: primary (specific) vagotonic phase and secondary (nonspecific) hypersympaticotonic phase. Changes in autonomic homeostasis accounted for the use of atropine sulfate for specific (antidote) therapy.
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