From ether extracts of the tunicate Cynthia savignyi, collected in Morocco, a new alkaloid-cynthichlorine-has been isolated. The structure of cynthichlorine has been characterized by extensive 2D-NMR data. Cynthichlorine possesses antifungal activity against two tomato pathogenic fungi: Botrytis cinerea and Verticillium albo atrum and antibacterial activity against Agrobacterium radiobacter, Escherichia coli and Pseudomonas aeruginosa and cytotoxicity against Artemia salina larvae.
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Cynthichlorine: a bioactive alkaloid from the tunicate Cynthia savignyi.
Farmaco
December 2003
Laboratoire de Chimie Organique Biomoléculaire Associé au C.N.R, Faculté des Sciences Ben M'Sik, BP 7955 Casablanca, Maroc.
From ether extracts of the tunicate Cynthia savignyi, collected in Morocco, a new alkaloid-cynthichlorine-has been isolated. The structure of cynthichlorine has been characterized by extensive 2D-NMR data. Cynthichlorine possesses antifungal activity against two tomato pathogenic fungi: Botrytis cinerea and Verticillium albo atrum and antibacterial activity against Agrobacterium radiobacter, Escherichia coli and Pseudomonas aeruginosa and cytotoxicity against Artemia salina larvae.
View Article and Find Full Text PDFIsolation and bioactivities of epidioxysterol from the tunicate Cynthia savignyi.
Farmaco
March 2001
Laboratoire de Chimie Organique Biomoléculaire Associé au CNR, Faculté des Sciences Ben M'Sik, Casablanca, Morocco.
Article Synopsis
- A new compound called epidioxysterol has been isolated from the tunicate Cynthia savignyi, marking the first time this compound has been found in this species.
- The structure of epidioxysterol was characterized using advanced NMR techniques, including 1H, 13C, and 2D NMR.
- This compound shows promising biological activities, exhibiting antifungal effects against three types of pathogenic fungi, antibacterial activity against several bacteria, and cytotoxicity against brine shrimp larvae.
Investigation of bioactivity of extracts from Moroccan solitary tunicate Cynthia savignyi.
J Ethnopharmacol
December 1999
Laboratoire de Chimie Organique Biomoléculaire Associé au C.N.R, Faculté des Sciences, Casablanca, Morocco.
Extracts of the tunicate Cynthia savignyi from the Moroccan Atlantic sea have been investigated in five bioassays. The first is an antibacterial test against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Agrobacterium tumefaciens; the second is an antifungal test against three tomato pathogenic fungi, Botrytis cinerea, Fusarium oxysporum and Verticillium albo-atrum; the third is a test based to the ability to reduce DNA peak size in procedures using an HPLC system for detection of antitumour agents; the fourth is a toxicity test using larva of Artemia salina; and the last is an enzymatic inhibitory test against papain and trypsin. For all the bioassays, extracts of C.
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