AI Article Synopsis
- The study compared the effectiveness of serum cystatin C and serum beta(2)-microglobulin (B2M) as markers for glomerular filtration rate (GFR) in kidney donors before and after surgery.
- After nephrectomy, GFR decreased significantly, with serum creatinine and urea levels rising notably, while cystatin C and B2M levels also increased.
- Serial measurements of serum creatinine outperformed B2M and cystatin C in detecting reduced kidney function, highlighting cystatin C's poor reliability due to high variation in individual results.
Article Abstract
Background: The usefulness of serum cystatin C and serum beta(2)-microglobulin (B2M) as markers of glomerular filtration rate (GFR) were compared in kidney donors before and after nephrectomy.
Methods: Blood samples were taken from 28 donors (15 women and 13 men) for serum creatinine, urea, cystatin C and B2M estimation a median of 7 days before and 10 days after nephrectomy.
Results: Estimated GFR decreased from a median of 86.2 mL/min/1.73 m(2) to 60.3 mL/min/1.73 m(2), a median decrease of 28.6%. Serum creatinine increased by 40% and urea by 30.4%; serum cystatin C increased by 31.2% and serum B2M increased by 65.6%. Using published data on biological variation, critical values were calculated. An increase in serum creatinine above 18 micro mol/L detected the decline in renal function in 26/28 (92.9%) subjects. Increases in serum B2M greater than a critical value of 0.94 mg/L detected 24/28 (85.7%) of these subjects, but the critical value of 0.59 mg/L for cystatin C detected only 8/28 (28.6%).
Conclusion: Using critical values, serial measurement of serum creatinine was better than serum B2M in detecting reduced renal function. Because of its large intraindividual variation, serial serum cystatin C estimation was very poor in detecting reduced renal function.
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| http://dx.doi.org/10.1258/000456303770367252 | DOI Listing |
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