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Ginkgolide B as a biopsychosocial treatment salvages repeated restraint stress-induced amygdalar anomalies in mice.
IBRO Neurosci Rep
June 2025
Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Oyo State, Nigeria.
From preclinical and clinical findings, it has been shown that the amygdala is a critical mediator of stress and primary target for stress effects in the brain. We investigated the neuroprotective effect of Ginkgolide B (GB) in repeated restraint stress-induced behavioral deficit and amygdalar inflammation in mice. Mice were orally pre-treated with GB 20 mg/kg 1 h prior to 4 h restraint stress for 21 consecutive days.
View Article and Find Full Text PDFBackground: Diabetes mellitus (DM) often leads to lower extremity amputations when poorly managed. Managing DM in Ghana is difficult due to limited access to diabetic care, low public awareness, and a strong reliance on religious beliefs and traditional medicine.
Aim: This study examined the lifestyle changes of patients after lower limb amputation at Sunyani Teaching Hospital (STH) in Ghana, using the biopsychosocial model.
Cross-cultural adaptation and validation of the Spanish version of the Prevent for Work questionnaire.
Front Public Health
January 2025
Department of GSpine4, IRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.
Background: Musculoskeletal pain represents an increase in medical expenses due to disability and decreased quality of life among workers. Various biopsychosocial factors contribute to the development of persistent and disabling musculoskeletal pain. The Prevent for Work questionnaire (P4Wq) intended to analyze these factors.
View Article and Find Full Text PDFDeveloping a translational research framework for MDD: combining biomolecular mechanisms with a spiraling risk factor model.
Front Psychiatry
January 2025
Department of Pharmaceutical Sciences and Freudenthal Institute, Utrecht University, Utrecht, Netherlands.
Objective: The global incidence and burden of Major Depressive Disorder (MDD) are increasing annually, with current antidepressant treatments proving ineffective for 30-40% of patients. Biomolecular mechanisms within the microbiota-gut-brain axis (MGBA) may significantly contribute to MDD, potentially paving the way for novel treatment approaches. However, integrating the MGBA with the psychological and environmental aspects of MDD remains challenging.
View Article and Find Full Text PDFThe potential impact of exercise on affect and neuroinflammation in older adults living with fibromyalgia: a scoping review.
Front Hum Neurosci
January 2025
Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Introduction: Fibromyalgia (FM) is a widespread chronic pain condition with prevalence increasing in older adults. Older adults living with FM experience longer pain symptom durations that can negatively impact their quality of life. Affect and neuroinflammation are potential factors that can exacerbate pain symptoms.
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