AI Article Synopsis
- The study examines how catecholamines, specifically dopamine and octopamine, influence memory formation in the fruit fly Drosophila melanogaster.
- It reveals that cAMP signaling is crucial for creating both appetitive (pleasure-related) and aversive (fear-related) olfactory memories, using the same type of neurons.
- Different catecholamines are required for different memory types: dopamine is needed for aversive memories, while octopamine is essential for appetitive memories, indicating a link to the motivational systems in associative conditioning.
Article Abstract
The catecholamines play a major role in the regulation of behavior. Here we investigate, in the fly Drosophila melanogaster, the role of dopamine and octopamine (the presumed arthropod homolog of norepinephrine) during the formation of appetitive and aversive olfactory memories. We find that for the formation of both types of memories, cAMP signaling is necessary and sufficient within the same subpopulation of mushroom-body intrinsic neurons. On the other hand, memory formation can be distinguished by the requirement for different catecholamines, dopamine for aversive and octopamine for appetitive conditioning. Our results suggest that in associative conditioning, different memories are formed of the same odor under different circumstances, and that they are linked to the respective motivational systems by their specific modulatory pathways.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740930 | PMC |
| http://dx.doi.org/10.1523/JNEUROSCI.23-33-10495.2003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Detection of Human GPCR Activity in Drosophila S2 Cells Using the Tango System.
Int J Mol Sci
December 2024
Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Osaka 920-1192, Japan.
G protein-coupled receptors (GPCRs) are essential cell surface proteins involved in transducing extracellular signals into intracellular responses, regulating various physiological processes. This study validated the use of the Tango assay, a sensitive method for detecting GPCR activation, in Schneider 2 (S2) cells, focusing on the human Dopamine Receptor D4 (DRD4). Plasmids encoding the LexA-tagged human DRD4 receptor and a luciferase reporter were co-transfected into S2 cells and stimulated with dopamine.
View Article and Find Full Text PDFDopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion.
PLoS Biol
November 2024
Program in Neuroscience and Behavioural Disorders, Duke-NUS Medical School, Singapore.
The brain must guide immediate responses to beneficial and harmful stimuli while simultaneously writing memories for future reference. While both immediate actions and reinforcement learning are instructed by dopamine, how dopaminergic systems maintain coherence between these 2 reward functions is unknown. Through optogenetic activation experiments, we showed that the dopamine neurons that inform olfactory memory in Drosophila have a distinct, parallel function driving attraction and aversion (valence).
View Article and Find Full Text PDFA neurotransmitter atlas of males and hermaphrodites.
Elife
October 2024
Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.
Mapping neurotransmitter identities to neurons is key to understanding information flow in a nervous system. It also provides valuable entry points for studying the development and plasticity of neuronal identity features. In the nervous system, neurotransmitter identities have been largely assigned by expression pattern analysis of neurotransmitter pathway genes that encode neurotransmitter biosynthetic enzymes or transporters.
View Article and Find Full Text PDFIndependent operations of appetitive and aversive conditioning systems lead to simultaneous production of conflicting memories in an insect.
Proc Biol Sci
September 2024
Research Institute for Electric Science, Hokkaido University, Sapporo 060-0812, Japan.
Pavlovian conditioning is a ubiquitous form of associative learning that enables animals to remember appetitive and aversive experiences. Animals possess appetitive and aversive conditioning systems that memorize and retrieve appetitive and aversive experiences. Here, we addressed a question of whether integration of competing appetitive and aversive information takes place during the encoding of the experience or during memory retrieval.
View Article and Find Full Text PDFA neurotransmitter atlas of males and hermaphrodites.
bioRxiv
June 2024
Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, USA.
Mapping neurotransmitter identities to neurons is key to understanding information flow in a nervous system. It also provides valuable entry points for studying the development and plasticity of neuronal identity features. In the nervous system, neurotransmitter identities have been largely assigned by expression pattern analysis of neurotransmitter pathway genes that encode neurotransmitter biosynthetic enzymes or transporters.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!