Facile N-arylation of amines and sulfonamides.

Org Lett

Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.

Published: November 2003

[reaction: see text] A facile, transition-metal-free N-arylation procedure for amines and sulfonamides has been developed, which affords good to excellent yields of arylated products under very mild reaction conditions. A methoxy-substituted aryl triflate affords N-arylated products in high yields with excellent regioselectivity. This chemistry tolerates a variety of functional groups.

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol0358612DOI Listing

Publication Analysis

Top Keywords

amines sulfonamides
8
facile n-arylation
4
n-arylation amines
4
sulfonamides [reaction
4
[reaction text]
4
text] facile
4
facile transition-metal-free
4
transition-metal-free n-arylation
4
n-arylation procedure
4
procedure amines
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!