[structure: see text] Two novel antimitotic heterocyclic alkaloids, ceratamines A (1) and B (2), have been isolated from the marine sponge Pseudoceratina sp., collected in Papua New Guinea. The structures of 1 and 2 were elucidated by analysis of spectroscopic data.
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http://dx.doi.org/10.1021/ol035721s | DOI Listing |
Eur J Med Chem
February 2025
School of Pharmacy, Fudan University, Shanghai, 201203, China; School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007, China. Electronic address:
ACS Biomater Sci Eng
November 2024
Institute of Nuclear Physics, Polish Academy of Sciences, Krakow PL-31342, Poland.
One of the most dangerous aspects of cancers is their ability to metastasize, which is the leading cause of death. Hence, it holds significance to develop therapies targeting the eradication of cancer cells in parallel, inhibiting metastases in cells surviving the applied therapy. Here, we focused on two melanoma cell lines─WM35 and WM266-4─representing the less and more invasive melanomas.
View Article and Find Full Text PDFLeukemia
December 2024
Department of Leukemia, The University of Texas MD Anderson Cancer center, Houston, TX, USA.
Lancet Oncol
October 2024
Prostate Cancer Theranostics and Imaging Centre of Excellence, Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
J Cell Sci
August 2024
Department of Anatomy and Developmental Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
The primary cilium is a small organelle protruding from the cell surface that receives signals from the extracellular milieu. Although dozens of studies have reported that several genetic factors can impair the structure of primary cilia, evidence for environmental stimuli affecting primary cilia structures is limited. Here, we investigated an extracellular stress that affected primary cilia morphology and its underlying mechanisms.
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