Our objective in this study was to determine the prevalence of reproductive and related nonreproductive morbidities in a group of reproductive-aged women living in Jordan. The study was designed as a two-phase survey. The first phase consisted of a structured personal interview and the second phase was a follow-up physical examination. Three hundred seventeen women aged 18-49 years were randomly selected and answered the questionnaire in the first phase of the study. Two hundred sixty agreed to both the general physical and pelvic examination. The main outcome measures were selected reproductive and related nonreproductive morbidities. Results show reproductive tract infections were diagnosed in 55% of the women, a presumed chlamydia trachomatis genital infection in 40%, and genital prolapse in 22%. As for related nonreproductive morbidities, 14% were diagnosed with a urinary tract infection (UTI), 24% with urinary incontinence, and 40% with anemia. Our results of the study support the idea that in this community, women's health is at risk throughout their reproductive years, not only when they are pregnant or postpartum. We suggest further research in other Jordanian communities as well as solutions addressed to the health care community.
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http://dx.doi.org/10.1080/07399330390217734 | DOI Listing |
Biol Sex Differ
December 2024
State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai, China.
Background: DNA methylation (DNAm) influences both sex differences and cancer development, yet the mechanisms connecting these factors remain unclear.
Methods: Utilizing data from The Cancer Genome Atlas, we conducted a comprehensive analysis of sex-related DNAm effects in nine non-reproductive cancers, compared to paired normal adjacent tissues (NATs), and validated the results using independent datasets. First, we assessed the extent of sex differential DNAm between cancers and NATs to explore how sex-related DNAm differences change in cancerous tissues.
Nucleic Acids Res
November 2024
College of Pharmaceutical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China.
The NIH policy on sex as biological variable (SABV) emphasized the importance of sex-based differences in precision oncology. Over 50% of clinically actionable oncology genes are sex-biased, indicating differences in drug efficacy. Research has identified sex differences in non-reproductive cancers, highlighting the need for comprehensive sex-based cancer data.
View Article and Find Full Text PDFJ Feline Med Surg
July 2024
University of Padova, Department of Animal Medicine, Production and Health, Legnaro, Padova, Italy.
Genes Chromosomes Cancer
July 2024
Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Neuroblastoma (NB) is a heterogeneous childhood cancer with a slightly higher incidence in boys than girls, with the reason for this gender disparity unknown. Given the growing evidence for the involvement of loss of the Y chromosome (LoY) in male diseases including cancer, we investigated Y chromosome status in NB. Male NB tumor samples from a Swedish cohort, analyzed using Cytoscan HD SNP-microarray, were selected.
View Article and Find Full Text PDFEur J Contracept Reprod Health Care
October 2024
Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
Background: Contraceptive methods are well-established in their ability to prevent pregnancy and increase individual agency in childbearing. Evidence suggests that contraceptives can also be used to treat adverse conditions associated with menstruation, including abnormal and prolonged uterine bleeding, heavy menstrual bleeding, painful menstruation, endometriosis, uterine fibroids, and premenstrual dysphoric disorders.This review investigates the effects of contraceptive techniques such as contraceptive pills, and long-acting reversible contraceptives (e.
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