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Activation of Local 11β-Hydroxysteroid Dehydrogenase Type 1 by Diosmetin Enhances Endogenous Glucocorticoid Levels to Alleviate Skin Inflammation: Insights Into a Novel Therapeutic Strategy for Atopic Dermatitis.
Exp Dermatol
February 2025
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Glucocorticoids (GCs) are synthesised de novo by peripheral tissues and the adrenal cortex of the hypothalamic-pituitary-adrenal axis. Skin expresses an enzyme called 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which reduces cortisone to the active hormone cortisol which activates GC receptors. 11β-HSD1 plays a significant role in alleviating atopic inflammation through the elevation of the concentrations of active GC in the skin.
View Article and Find Full Text PDFDiversity of complementary diet and early food allergy risk.
Pediatr Allergy Immunol
January 2025
Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Introduction: Diet diversity (DD) in infancy may be protective for early food allergy (FA) but there is limited knowledge about how DD incorporating consumption frequency influences FA risk.
Methods: Three measures of DD were investigated in 2060 infants at 6 and/or at 9 months of age within the NorthPop Birth Cohort Study: a weighted DD score based on intake frequency, the number of introduced foods, and the number of introduced allergenic foods. In multivariable logistic regression models based on directed acyclic graphs, associations to parentally reported physician-diagnosed FA at age 9 and 18 months were estimated, including sensitivity and stratified analyses.
Knowledge, Attitude, Awareness, and Practice Regarding Mites Among the Thai Population.
Patient Prefer Adherence
January 2025
Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Background: mites are common ectoparasites in humans and can cause various skin disorders known as demodicosis, ranging from nonspecific facial dermatitis to conditions resembling eczema, seborrheic dermatitis, folliculitis, and acne. Overgrowth of these mites can lead to pityriasis folliculorum, perioral dermatitis, blepharitis, and rosacea, significantly impacting skin health. This study aims to investigate the knowledge, attitude, awareness, and practice regarding mites in the Thai population and analyze the influencing factors associated with these aspects.
View Article and Find Full Text PDFAsthma Risk Prevalence and Associated Factors in Stunted Children: A Study Using Asthma Predictive Index.
Medicina (Kaunas)
January 2025
Division of Allergy Immunology, Department of Child Health, Doctoral Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung 45363, West Java, Indonesia.
: The prevalence of stunted children under 5 years in Indonesia is relatively high. Stunting is a significant risk factor for wheezing disorders. The asthma predictive index (API) identifies children with a recurrent wheezing disorder at risk of developing asthma during the first 3 years.
View Article and Find Full Text PDFTinea Blepharociliaris: A Case Report and Literature Review.
Cureus
December 2024
General Practice, Autonomous University of Campeche, Campeche, MEX.
Tinea blepharociliaris is a rare dermatophyte infection affecting the eyelashes and eyelids, often misdiagnosed as blepharitis, eczema, or bacterial infection, leading to ineffective treatments and recurrent symptoms. We report a case of a 10-year-old girl with erythematous plaques and fine scaling on the eyelids and eyelashes, initially suspected to have facial tinea or contact dermatitis. Direct mycological examination confirmed the presence of fungal filaments and spores, with culture identifying as the causative organism.
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