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SARS-CoV-2 Transmission during High-Altitude Field Studies.
High Alt Med Biol
September 2024
Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Grimm, Mirjam, Lucie Ziegler, Annina Seglias, Maamed Mademilov, Kamila Magdieva, Gulzada Mirzalieva, Aijan Taalaibekova, Simone Suter, Simon R. Schneider, Fiona Zoller, Vera Bissig, Lukas Reinhard, Meret Bauer, Julian Müller, Tanja L. Ulrich, Arcangelo F.
View Article and Find Full Text PDFLong-term oncological and functional follow-up in low-dose-rate brachytherapy for prostate cancer: results from the prospective nationwide Swiss registry.
BJU Int
June 2020
Department of Urology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland.
Objective: To evaluate the long-term oncological, functional and toxicity outcomes of low-dose-rate brachytherapy (LDR-BT) in relation to risk factors and radiation dose in a prospective multicentre cohort.
Patients And Methods: Data of patients from 12 Swiss centres undergoing LDR-BT from September 2004 to March 2018 were prospectively collected. Patients with a follow-up of ≥3 months were analysed.
The tyranny of choice: reproductive selection in the future.
J Law Biosci
August 2018
Law School, The George Washington University, Washington, DC 20052, USA.
This article explores the enormous challenges to reproductive decision making that could result from two emerging technologies: the potential capacity to create vast numbers of embryos for preimplantation genetic diagnosis and the ability to obtain ever more predictive information about the embryo. Together these technologies could change our reproductive experience, exacerbate existing inequities, and profoundly affect reproductive decision making. Simply comprehending the dizzying amounts of predictive information about the health and traits of future children will overwhelm future parents.
View Article and Find Full Text PDFTLR8 activation and inhibition by guanosine analogs in RNA: Importance of functional groups and chain length.
Bioorg Med Chem
January 2018
Department of Chemistry, University of California, One Shields Ave, Davis, CA 95616, United States. Electronic address:
Toll-like receptor 8 (TLR8) is an important component of the human innate immune system that recognizes single stranded RNA (ssRNA). Recent X-ray crystal structures of TLR8 bound to ssRNA revealed a previously unrecognized binding site for a 5'-UpG-3' dinucleotide. Here we use an atomic mutagenesis strategy coupled with a cellular TLR8 activation assay to probe the importance of specific functional groups present on the guanine base in RNA-mediated receptor agonism and antagonism.
View Article and Find Full Text PDFResponsiveness of the Neuromuscular Recovery Scale During Outpatient Activity-Dependent Rehabilitation for Spinal Cord Injury.
Neurorehabil Neural Repair
July 2016
The Ohio State University, Columbus, OH, USA
Background: The Neuromuscular Recovery Scale (NRS) was developed by researchers and clinicians to functionally classify people with spinal cord injury (SCI) by measuring functionally relevant motor tasks without compensation. Previous studies established strong interrater and test-retest reliability and validity of the scale.
Objective: To determine responsiveness of the NRS, a version including newly added upper-extremity items, in an outpatient rehabilitation setting.
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