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Phytochemical Composition, Antibacterial, and Antibiotic-Resistance Modulatory Activity of Extracts of Moldenke M. A. Lawson, and L. Against Multidrug-Resistant .
Scientifica (Cairo)
December 2024
Department of Biochemistry, University of Dschang, Dschang, Cameroon.
is a critical-class pathogen that shows great resistance to most conventional antibiotics. Hence, it is of utmost importance to search for novel drugs to fight infections caused by this bacterium. This study aimed to evaluate the antibacterial activity of and extracts alone and in combination with antibiotics against multidrug-resistant (MDR) .
View Article and Find Full Text PDFDye-laden wastewater poses a significant environmental and health threat. This study investigated the potential of green-synthesized zinc oxide nanoparticles (ZnO NPs), derived from Padina pavonica brown algae extract, for the removal of methylene blue (MB) dye. The hypothesis was that utilizing algal extract for ZnO NP synthesis would enhance adsorption capacity and photocatalytic activity for dye removal.
View Article and Find Full Text PDFMachine learning enhances genotoxicity assessment using MultiFlow® DNA damage assay.
Environ Mol Mutagen
December 2024
Research and Development, Preclinical Safety, Sanofi, Industriepark Hoechst, Frankfurt am Main, Germany.
Genotoxicity is a critical determinant for assessing the safety of pharmaceutical drugs, their metabolites, and impurities. Among genotoxicity tests, mechanistic assays such as the MultiFlow® DNA damage assay (MFA) allows the investigations on mode of action (MoA) of DNA damage through four mechanistic markers recorded at two time points. Previous studies have shown that machine learning (ML) can enhance precision on classifying the MoA of genotoxicants.
View Article and Find Full Text PDFExploration of bioactive molecules from Sesbania grandiflora (L.): identification of squalene as an effective compound against the two-spotted spider mite, Tetranychus urticae Koch, through molecular docking.
Exp Appl Acarol
December 2024
Department of Agricultural Entomology, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India.
Two-spotted spider mite (TSSM), Tetranychus urticae Koch is a devastating polyphagous mite causing considerable economic loss. Acaricides are showered in crops to manage this pest. The pest is known for developing resistance to several classical acaricides.
View Article and Find Full Text PDFPredicting patients' sentiments about medications using artificial intelligence techniques.
Sci Rep
December 2024
SDU Health Informatics and Technology, The Maersk Mc-Kinney Moller Institute, University of Southern Denmark, Odense, Denmark.
The increasing development of technology has led to the increase of digital data in various fields, such as medication-related texts. Sentiment Analysis (SA) in medication is essential to give clinicians insights into patients' feedback about the treatment procedure. Therefore, this study intends to develop Artificial Intelligence (AI) models to predict patients' sentiments.
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