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Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.
Front Endocrinol (Lausanne)
December 2024
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Background: Observational studies suggest the risk of primary ovarian insufficiency (POI) is increased in autoimmune disorders (AIDs), but it is unclear whether there is a causal relationship. Therefore, we aimed to investigate the bidirectional causality between 20 AIDs and POI using Mendelian randomization (MR) analysis.
Methods: A bidirectional two-sample MR investigation was designed by using publicly accessible summary-level data from genome-wide association studies (GWAS).
Atypical presentation of Addison's disease with chest pain and dizziness: A case report and literature review.
Semergen
December 2024
Departamento de Cirugía, Facultad de Medicina y Odontología, Universidad de Valencia, Valencia, Spain.
Summary: An oral contraceptive pill (OCP)-induced increase in total cortisol lead to reversible suppression of the hypothalamic-pituitary-adrenal (HPA) axis and insulin resistance (IR) in a patient with Addison's disease. We suggest that this might influence the choice of an OCP in such patients. A 20-year-old female was diagnosed with Addison's disease (cortisol: 44 nmol/L, adrenocorticotropic hormone (ACTH): >500 pg/mL) and started on hydrocortisone (HC).
View Article and Find Full Text PDFNon-Contact Monitoring of Inhalation-Exhalation (I:E) Ratio in Non-Ventilated Subjects.
IEEE J Transl Eng Health Med
December 2024
Acute Care and Monitoring, Medtronic Boulder CO USA.
The inhalation-exhalation (I:E) ratio, known to be an indicator of respiratory disease, is the ratio between the inhalation phase and exhalation phase of each breath. Here, we report on results from a non-contact monitoring method for the determination of the I:E ratio. This employs a depth sensing camera system that requires no sensors to be physically attached to the patient.
View Article and Find Full Text PDFClinical findings, treatment, and outcomes in cats with naturally occurring hypoadrenocorticism: 41 cases.
J Vet Intern Med
December 2024
University of Bologna, Bologna, Italy.
Article Synopsis
- Hypoadrenocorticism in cats is rare, often presenting with abnormal serum sodium and potassium levels, but some cases show normal values; a study analyzed 41 cats with varying results.* -
- The study found that cats with electrolyte imbalances were more likely to exhibit symptoms like hypothermia and weakness, while over half of the subjects (85.4%) were discharged after treatment.* -
- About one-third of the cats showed hypercalcemia, and those without serious underlying conditions often had a good prognosis post-hospitalization; testing for exocrine pancreatic insufficiency is recommended.*
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