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Friedreich Ataxia: An (Almost) 30-Year History After Gene Discovery.
Neurol Genet
February 2025
Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
In the late 1800s, Nikolaus Friedreich first described "degenerative atrophy of the posterior columns of the spinal cord," noting its connection to progressive ataxia, sensory loss, and muscle weakness, now recognized as Friedreich ataxia (FRDA). Renewed interest in the disease in the 1970s and 80s by the Quebec Cooperative Group and by Anita Harding led to the development of clinical diagnostic criteria and insights into associated biochemical abnormalities, although the primary defect remained unknown. In 1988, Susan Chamberlain mapped FRDA's location on chromosome 9.
View Article and Find Full Text PDFNew moderationism: medical discourses on alcohol and the decline of drunkenness in interwar Britain.
Mod Br Hist
January 2025
Graduate School of Business Administration, Hitotsubashi University, Tokyo, Japan.
This article explores the significant yet underappreciated role of medical experts in consolidating the promotion of moderate drinking as a viable solution to Britain's alcohol problem during the interwar period. The country's experience with alcohol regulation in the First World War showed that widespread drunkenness could be effectively managed through policies that restricted the availability of alcohol and encouraged moderation. This realization weakened the political standing of the temperance movement, as support for alcohol prohibition and abstinence waned, leading to the liberalization of social attitudes towards drinking.
View Article and Find Full Text PDFA mixed method exploration of job morale of physicians working in public healthcare settings in Kazakhstan during the COVID-19 pandemic.
J Health Popul Nutr
January 2025
Department of Surgery, Astana Medical University, Astana, Kazakhstan.
Background: Physicians faced increased workloads during the COVID-19 pandemic, which exposed them to considerable physical and psychological stress. Gaining insight into shapers of job morale of physicians can help healthcare administrators assess the effectiveness of current work conditions and support systems, enabling them to develop policies that improve work environments and prepare healthcare systems for future resurgences of COVID-19 and other future unknown challenges. Therefore, the present study aimed to improve the understanding of physicians' experiences of job morale in Kazakhstan during the COVID-19 pandemic.
View Article and Find Full Text PDFTransforming medical education in the AI era: Balancing technological expertise with humanistic care in tomorrow's doctors.
Ann Acad Med Singap
December 2024
Group Clinical Education, National Healthcare Group, Singapore.
Community Building in Crisis: Interventions With Displaced Communities in Temporary Housing Shelters.
J Community Psychol
January 2025
School of Social Work, University of Haifa, Haifa, Israel.
Emergency displacement is a widespread phenomenon impacting all facets of life and increasing rates of psychological trauma. This article analyzes the effects of shared residency among evacuated and fragmented communities, focusing on social and communal disparities in temporary shelters. By adopting theoretical perspectives of community building and social capital, it describes interventions aimed at promoting resilience within newly formed shelter communities.
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