In the paper, methodological requirements are formulated for validation of permissible levels of benz(a)pyrene (B(a)P) in foodstuffs. A list is submitted of allowable levels of this carcinogen in food products for the population of Ukraine, their specific values being dependent on the accepted tolerance daily done intake and on the structure of the standard food ration. Prevention of B(a)P formation and its elimination from the human habitat together with the use of the modern environmentally appropriate technologies designed to prepare food products will form a basis for stabilization of the permissible dose of the carcinogen, finding its way to the human body as a food component through dietary intake.
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Molecules
May 2024
Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
In aqueous and solid media, 2-HP-β/γ-CD inclusion complexes with poly aromatic hydrocarbon (PAH) Phenanthrene (PHN), Anthracene (ANT), Benz(a)pyrene (BaP), and Fluoranthene (FLT) were investigated for the first time. The inclusion complexes were characterized and investigated using fluorescence and HNMR spectroscopy. The most prevalent complexes consisting of both guests and hosts were those with a 1:1 guest-to-host ratio.
View Article and Find Full Text PDFBioinformation
September 2022
Central Research Laboratory, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research, Kanchipuram Tamil Nadu, India - 631552.
Female breast cancer is the leading malignancy surpassing lung cancer recently, and its incidence is continued to rise in many countries. The existing anticancer drugs have limitations like drug resistance and adverse effects leading to poor clinical outcomes. The natural compounds withaferin-A and propolis have been individually reported for their anticancer activity in preclinical models.
View Article and Find Full Text PDFClin Epigenetics
May 2019
Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, 722 West 168th Street, New York, NY, 10032, USA.
Background: Epidemiological studies have found that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with increased risk for neural tube defects (NTDs). Aberrant DNA methylation, excessive apoptosis, and oxidative stress have been implied as the mechanism underlying the association between PAH exposure and NTDs, respectively. However, the role of DNA methylation aberration of apoptotic initiator CASP8 (caspase-8, apoptosis-related cysteine peptidase) in the formation of NTDs in association with PAH exposure is not known.
View Article and Find Full Text PDFThe authors performed investigations of the content of polycyclic aromatic hydrocarbons (PAH) (n = 17) and their nitro derivatives (n = 5) in commercial cold and hot smoked herrings and greenlings. The level of benz(a)pyrene in all fish samples was found to be well below the current sanitary and hygienic limits. The concentration of N-nitrosoamines in cold smoked fish was slightly below that in hot smoked one.
View Article and Find Full Text PDFOutbred female SHR mice (n=200) were divided at random into 4 groups, 50 per group. Benz(a)pyrene solution in acetone was applied onto a skin site on the back during 26 weeks. In parallel, the animals received melatonin, metformin, or both.
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