As many as 314 patients with functional class I-III ischemic heart disease (IHD) who had been placed on a long-term (3-year) monotherapy with propranolol were examined. Under a long-term administration of a beta-adrenoblocking agent no suppression has been seen of the contractile capability of the myocardium; there is noted an improvement in hemorheologic disturbances and a significantly greater improvement in the clinical course of the illness--it has been found out the therapy prevents transformation of angina of high effort to angina of low effort.

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