[Combined use of anaprilin and thiamine in the treatment of ischemic heart disease].

In 60 patients with stable functional class II exertional angina with hyperkinetic type of circulation, baseline hemodynamics was studied following a 2-week treatment. A negatively chrono- and inotrophic effect was observed with taking anaprilin in a dose of 160 mg per day and a dose of 80 mg per day combined with 2 ml of 5 per cent solution of thiamine-chloride in injections. No effect was elicited with an 80 mg/d anaprilin without thiamine. The use of anaprilin and thiamine combined in treatment of IHD patients permits to reduce doses of beta-adrenoblockers as large doses of it may result in heart failure.