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In vivo systemic vancomycin determination from polymethyl methacrylate and morselized bone allograft used in two stage septic knee revision arthroplasty.
Germs
September 2024
MD, PhD, Professor, Department of Orthopedics, Carol Davila University of Medicine and Pharmacy, No. 8 Eroii Sanitari Boulevard, Bucharest, 050474, Romania.
Introduction: This paper examines the use of local antibiotic therapy in one-stage septic revision surgery for late periprosthetic joint infections (PJIs). This case study suggests that morselized bone allografts impregnated with antibiotics in powder form are a preferable alternative to polymethyl methacrylate (PMMA) because they can generate higher local antibiotic concentrations. Current research also recommends using vancomycin and aminoglycosides as the preferred choice of antibiotics, as they may have low diffusion in tissues when administered intravenously, but are effective when administered locally.
View Article and Find Full Text PDFOne-Piece Monolithic Zirconia Single Tooth Implant-Supported Restorations in the Posterior Region: A 1-Year Prospective Case Series Study.
Clin Oral Implants Res
December 2024
Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Objective: To assess the clinical, radiographic and patient-reported outcome measures, and the success of screw-retained one-piece monolithic zirconia implant-supported restorations in the posterior region during a 1-year follow-up.
Methods: In a prospective case series, 50 single molar sites in the posterior region of 41 patients with a minimum age of 18 years and sufficient bone volume for placing an implant (≥ 8 mm) and space for an anatomical restoration were included. Following prosthetic-driven digital three-dimensional treatment planning, a tissue-level implant with an internal connection was inserted during a one-stage surgical procedure.
Clinical Experience of Dissolvable Calcium Sulfate (Stimulan) Carrier for Antibiotic Delivery in Orthopedic Surgery: A Study of 143 Patients.
J Long Term Eff Med Implants
December 2024
St. Joseph's Hospital, Paterson, New Jersey, USA.
Prosthetic bone and joint infections are difficult to treat with varying levels of success with standard therapy. Synthetic calcium sulfate carrier, to which specific antibiotics can be added, can be utilized as an alternative drug delivery system in these cases. We have reviewed clinical outcomes using commercially available pure synthetic calcium sulfate dissolvable beads (Stimulan) loaded with antibiotics in 143 patients undergoing orthopedic surgery for prevention and treatment of joint infection.
View Article and Find Full Text PDFIs the Presence of Sinus Tract in Periprosthetic Joint Infection Still One of the Main Deciding Factors for Septic Revision?
Cureus
December 2024
Orthopaedics and Traumatology, "Carol Davila" Faculty of Medicine, Bucharest, ROU.
Introduction Two of the most common complications of joint arthroplasty surgery are aseptic and septic loosening. While aseptic loosening has a well-established treatment protocol, and diagnosis is quite straightforward, bacterial colonization of the implants is associated with a more difficult diagnosis and treatment, more surgeries, and higher morbidity for the patient. Accurate diagnosis is essential in choosing the right treatment plan.
View Article and Find Full Text PDFThe relationship between the secondary implant stability quotient and oxidized implant-related factors: A retrospective study.
Heliyon
October 2024
Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia.
Objective: The present retrospective study aimed to determine the relationship between the secondary implant stability quotient and different parameters related to an oxidized implant.
Methods: A total of 135 patients (305 oxidized implants) were included. Implant-related factors (length, diameter, surgical and loading protocols, grafting, insertion torque, and primary stability) were used for comparisons and linear regression analyses, using secondary ISQ as the dependent variable.
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