AI Article Synopsis
- Southeast Asian ovalocytosis (SAO) is a red blood cell abnormality linked to a genetic deletion in the band 3 protein gene, prevalent in malaria-prone areas.
- Researchers studied the occurrence of SAO in 22 patients with distal renal tubular acidosis (dRTA) and 50 healthy individuals in Malaysia.
- The results showed a significantly higher incidence of SAO in dRTA patients (81.8%) compared to healthy controls (4%), suggesting a dysfunction of the band 3 protein in dRTA development.
Article Abstract
Southeast Asian ovalocytosis (SAO) is a red blood cell abnormality common in malaria-endemic regions and caused by a 27 nt deletion of the band 3 protein gene. Since band 3 protein, also known as anion exchanger 1, is expressed in renal distal tubules, the incidence of SAO was examined in distal renal tubular acidosis (dRTA) in Malays in Kelantan, Malaysia. Twenty-two patients with dRTA and 50 healthy volunteers were examined for complication of SAO by both morphological and genetic analyses. SAO was identified in 18 of the 22 dRTA patients (81.8%), but only two of the 50 controls (4%). The incidence of SAO was significantly high in those with dRTA (p<0.001), indicating a dysfunctional role for band 3 protein/anion exchanger 1 in the development of dRTA.
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| http://dx.doi.org/10.1007/s10038-003-0095-2 | DOI Listing |
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