The development of a new vowel category was studied by measuring both automatic mismatch negativity and conscious behavioural target discrimination. Three groups, nai;ve Finns, advanced Finnish students of English, and native speakers of English, were presented with one pair of Finnish and three pairs of English synthetic vowels. The aim was to determine whether the advanced student group would show native-like responses to the unfamiliar vowel contrasts of the target language. The results suggest that learning in classroom environment may not lead to the formation of new long-term native-like memory traces.
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http://dx.doi.org/10.1016/j.neulet.2003.08.013 | DOI Listing |
J Neurol
January 2025
Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Fundació de Recerca Clínic - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Villaroel 170, 08036, Barcelona, Spain.
Plasma tau phosphorylated at threonine 181 (p-tau181) and 217 (p-tau217) have demonstrated high accuracy for Alzheimer's disease (AD) diagnosis, defined by CSF/PET amyloid beta (Aβ) positivity, but most studies have been performed in research cohorts, limiting their generalizability. We studied plasma p-tau217 and p-tau181 for CSF Aβ status discrimination in a cohort of consecutive patients attending an academic memory clinic in Spain (July 2019-June 2024). All patients had CSF AD biomarkers performed as part of their routine clinical assessment.
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January 2025
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
The objective of this study was to examine the association between serum tacrolimus trough levels and the detection of BK viruria in kidney transplant recipients. We conducted a retrospective study and included kidney transplant recipients who underwent BK viruria screening during 2018-2021. Serum tacrolimus trough levels, urine BK viral load, and potential risk factors were collected.
View Article and Find Full Text PDFDiscov Immunol
December 2024
Laboratory of Functional Genomics and Medicine, Division of Biological Science, Nara Institute of Science and Technology (NAIST), Ikoma-shi, Nara, Japan.
Introduction: Programmed death-1 (PD-1) is a negative regulator of immune responses. Upon deletion of PD-1 in mice, symptoms of autoimmunity developed only after they got old. In a model experiment in cancer immunotherapy, PD-1 was shown to prevent cytotoxic T lymphocytes from attacking cancer cells that expressed neoantigens derived from genome mutations.
View Article and Find Full Text PDFMod Pathol
January 2025
Department of Pathology, University of Pittsburgh Medical Center and the University of Pittsburgh, Pittsburgh, PA. Electronic address:
Claudin 18.2 (CLDN18.2) immunohistochemical expression can be used to select patients with gastric/gastroesophageal junction adenocarcinomas for zolbetuximab (IMAB362) therapy, a monoclonal antibody targeting CLDN18.
View Article and Find Full Text PDFBrain Lang
January 2025
Univ. Lille, CNRS, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, F-59000 Lille, France; Univ. Lille, Inria, CNRS, Centrale Lille, UMR 9189 - CRIStAL, F-59000, Lille, France. Electronic address:
Although previous research has shown that speakers adapt on the words they use, it remains unclear whether speakers adapt their phonological representations, leading them to perceive new phonemic contrasts following a social interaction. This event-related potential (ERP) study investigates whether the neuronal responses to the perception of the /e/-/ε/ vowel merger in Northern French speakers show evidence for discriminating /e/ and /ε/ phonemes after interacting with a speaker who produced this contrast. Northern French participants engaged in an interactive map task and we measured their ERP responses elicited after the presentation of a last syllable which was either phonemically identical to or different from preceding syllables.
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