Objective: To find the optimum screening method in detecting group B streptococcal (GBS) colonization in both mother and infant, and to identify the risk factors that influence GBS colonization in the infants.
Patients And Methods: 1,120 singleton pregnant women were evaluated for GBS colonization by combined lower vaginal-anorectal swabs (LVRS) and urine tests, while their infants were evaluated for colonization with skin, ear and gastric aspirate samples.
Results: LVRS swabs were positive in 14.2% of mothers while urine was positive in 7.6%. Among the infants skin, ear and gastric aspirate samples were positive in 7.0, 6.9 and 3.5%, respectively. Prolonged rupture of the membrane was the only significant factor associated with colonization in these infants (p < 0.001).
Conclusions: Lower vaginal-anorectal swab is an effective method in detecting colonization in mothers especially when combined with urine culture. Skin or ear swabs are equally effective in detecting colonization in neonates. GBS colonization rate in our parturient and neonatal population is comparable to that was reported from other countries. A well-developed screening program and appropriate management strategies for both GBS colonized mothers and infants are recommended.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000074825 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genotype Distribution and High-Risk Factors Analysis of Group B Streptococcus in Late-Stage Pregnant Women in the Linyi Region.
Int J Microbiol
December 2024
Key Laboratory of Birth Defects, Women's & Children's Health Care Hospital of Linyi, Linyi 276000, Shandong, China.
To understand the colonization status of Group B Streptococcus (GBS) in the reproductive tract of pregnant women in the Linyi region, the drug resistance, genotype distribution, and molecular epidemiological characteristics of GBS, and to explore the high-risk factors for GBS infection in late-stage pregnant women. A total of 3269 pregnant women at 35-37 weeks of gestation who visited the Obstetrics Department of Linyi Maternal and Child Health Hospital from January 2019 to December 2021 were selected as the study subjects. Vaginal and rectal swabs were collected for GBS culture.
View Article and Find Full Text PDFComparing the safety of a single balloon catheter to dinoprostone for inducing labor in pregnant women with group B Streptococcus vaginal colonization: An observational study.
Medicine (Baltimore)
December 2024
Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China.
Group B Streptococcus is a bacterium that colonizes in approximately 20% of pregnant women and can be vertically transmitted to newborns, leading to maternal-neonatal adverse outcomes, such as chorioamnionitis, neonatal sepsis, and pneumonia. However, there is currently no agreement on the optimal induction method for this specific population. This study aims to evaluate the safety of a single balloon catheter (BC) in comparison to dinoprostone for labor induction in term pregnant women with group B Streptococcus colonization.
View Article and Find Full Text PDFMaternal group B decreases infant length and alters the early-life microbiome: a prospective cohort study.
Ann Med
December 2025
Department of Laboratory Medicine, Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Background: Maternal colonization with Group B Streptococcus (GBS) disrupts the vaginal microbiota, potentially affecting infant microbiota assembly and growth. While the gut microbiota's importance in infant growth is recognized, the specific effects of maternal GBS on growth remain unclear. This study aimed to explore the effects of maternal vaginal GBS during pregnancy on early infant growth, microbiome, and metabolomics.
View Article and Find Full Text PDFDiversity in Naturally Acquired Immunity to Group B Streptococcus: A Comparative Study of Women from Bangladesh, Malawi, and the United Kingdom.
J Infect Dis
December 2024
Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, United Kingdom.
Background: Significant disparities in Group B Streptococcus (GBS) colonisation and neonatal disease rates have been documented across different geographical regions. For example, Bangladesh reports notably lower rates compared to the United Kingdom (UK) and Malawi. This study investigates whether this epidemiological variability correlates with the immune response to GBS in these regions.
View Article and Find Full Text PDFA CRISPRi Library Screen in Group B Identifies Surface Immunogenic Protein (Sip) as a Mediator of Multiple Host Interactions.
bioRxiv
December 2024
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Group B (GBS; ) is an important pathobiont capable of colonizing various host environments, contributing to severe perinatal infections. Surface proteins play critical roles in GBS-host interactions, yet comprehensive studies of these proteins' functions have been limited by genetic manipulation challenges. This study leveraged a CRISPR interference (CRISPRi) library to target genes encoding surface-trafficked proteins in GBS, identifying their roles in modulating macrophage cytokine responses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!