The probabilities of the various possible identity by descent (IBD) states at a locus captures all the genealogical information for that locus for the set of individuals under consideration. Here we study the stochastic process of the IBD state as one moves across the genome of a set of individuals. In general it is no longer sufficient to specify the IBD state, one needs to increase the state space if one is to maintain the Markov property, as has been discussed by for instance McPeak and Sun [Am J Hum Genet 2000;66:1076-1094] and Browning and Browning [Theor Popul Biol 2002;62:1-8]. This paper discusses a general method of deriving the transition matrix for that Markov chain iteratively from one time point to a subsequent one. This method allows a considerable reduction in the size of the state space needed. The basic recursion is set out here and the application is illustrated by two specific examples.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1159/000073740 | DOI Listing |
Sci Adv
December 2024
Institute of Archaeogenomics, HUN-REN Research Centre for the Humanities, Budapest, Hungary.
Curr Biol
November 2024
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:
Free-breeding dogs have occupied the Galápagos Islands at least since the 1830s; however, it was not until the 1900s that dog populations grew substantially, endangering wildlife and spreading disease. In 1981, efforts to control the population size of free-roaming dogs began. Yet, there exist large free-roaming dog populations on the islands of Isabela and Santa Cruz whose ancestry has never been assessed on a genome-wide scale.
View Article and Find Full Text PDFPlants (Basel)
November 2024
State Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China.
The selection of unique and individual-specific SNPs is important as compared with universal SNPs for individual identification. Therefore, the main significance of this research is the selection of specific SNPs in male parent and the identification of offspring with these specific SNPs in their genome by multiplex PCR, which is utilized for genotyping of 332 half-sib plants of .This cost-effective method makes as much as possible to utilize the same amount of each pair of various targeted loci primers.
View Article and Find Full Text PDFNat Commun
November 2024
Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!