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Digital Home-Based Self-Monitoring System for People with Heart Failure: Protocol for Development of SmartHeart and Evaluation of Feasibility and Acceptability.
JMIR Res Protoc
January 2025
School of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition, Deakin University, Burwood, Australia.
Background: Heart failure (HF) is a chronic, progressive condition where the heart cannot pump enough blood to meet the body's needs. In addition to the daily challenges that HF poses, acute exacerbations can lead to costly hospitalizations and increased mortality. High health care costs and the burden of HF have led to the emerging application of new technologies to support people living with HF to stay well while living in the community.
View Article and Find Full Text PDFERMP1 as a newly identified ER stress gatekeeper in chronic kidney disease.
Am J Physiol Renal Physiol
January 2025
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
ERMP1 is involved in the Unfolded Protein Response (UPR) pathway in response to endoplasmic reticulum (ER) stress. Given the pivotal role of ER stress in the pathogenesis of acute and chronic kidney diseases, we hypothesized that ERMP1 could be instrumental in the development of renal injury. analysis of RNA sequencing datasets from renal biopsies were exploited to assess the expression of ERMP1 in the kidney under normal or pathological conditions.
View Article and Find Full Text PDF(), a Gram-negative bacterium commonly found in aquatic environments, has the capacity to be transmitted to humans through consumption of contaminated fish, water, or seafood. In this study, we present a case report concerning a 77-year-old female patient who experienced an acute exacerbation of chronic heart failure, subsequently developing severe septic shock due to necrotizing fasciitis caused by . Infections caused by are more prevalent during warmer months, particularly in regions characterized by dense aquaculture or the presence of natural water bodies.
View Article and Find Full Text PDFEpidemiological Analysis of Respiratory Diseases in Mexico From 2000 to 2020: Trends, Geographic Distribution, and Public Health Challenges.
Cureus
December 2024
Faculty of Biology, Autonomous University of Sinaloa, Culiacan, MEX.
Introduction: In Mexico, respiratory diseases such as tuberculosis (TB), acute respiratory infections (ARI), pertussis (Pt), and pneumonia-bronchopneumonia (Nemu) represent critical public health challenges that contribute to morbidity and mortality and are exacerbated by socioeconomic factors and the COVID-19 pandemic.
Objective: To evaluate the trends, seasonal patterns, and geographic distribution of major respiratory diseases in Mexico between 2000 and 2020.
Methodology: Data from the National Epidemiologic Surveillance System were analyzed using advanced statistical methods, including Kruskal-Wallis tests, Mann-Whitney analysis, and multivariate analysis, to identify temporal and regional variations.
Abnormal adipose tissue-derived microbes drive metabolic disorder and exacerbate postnatal growth retardation in piglet.
Life Metab
April 2024
College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410000, China.
Postnatal growth retardation (PGR) frequently occurs during early postnatal development of piglets and induces high mortality. To date, the mechanism of PGR remains poorly understood. Adipose tissue-derived microbes have been documented to be associated with several disorders of metabolism and body growth.
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