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Efficacy of colistin-based combinations against pandrug-resistant whole-genome-sequenced Klebsiella pneumoniae isolated from hospitalized patients in Egypt: an in vitro/vivo comparative study.
Gut Pathog
December 2024
Microbiology and Immunology Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Background: Colistin resistance significantly constrains available treatment options and results in the emergence of pandrug-resistant (PDR) strains. Treating PDR infections is a major public health issue. A promising solution lies in using colistin-based combinations.
View Article and Find Full Text PDFConventionally Reared Wallon Meat Lambs Carry Transiently Multi-Drug-Resistant with Reduced Sensitivity to Colistin Before Slaughter.
Animals (Basel)
October 2024
Department of Food Sciences, Microbiology, Fundamental and Applied Research for Animal & Health (FARAH), Faculty of Veterinary Medicine, Université de Liège, Avenue de Cureghem 10, 4000 Liège, Belgium.
Major efforts have been made to reduce the use of colistin in livestock since the discovery of the plasmid-borne mobile colistin resistance () gene in a decade ago, to curb the burden of its potential transmission to other bacterial species, spread between animals, humans and the environment. This study explored the longitudinal prevalence and characteristics of colistin-resistant and extended-spectrum beta-lactamase-producing (ESBL) via in vivo fecal and ex vivo carcass swabs from two batches of conventional indoor and organic outdoor Wallon meat sheep from birth to slaughter in 2020 and 2021. Antimicrobial susceptibility testing via broth microdilution revealed that n = 16/109 (15%) isolates from conventional meat lamb fecal samples had a reduced colistin sensitivity (MIC = 0.
View Article and Find Full Text PDFDiversity, functional classification and genotyping of SHV β-lactamases in .
Microb Genom
October 2024
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Interpreting the phenotypes of alleles in genomes is complex. Whilst all strains are expected to carry a chromosomal copy conferring resistance to ampicillin, they may also carry mutations in chromosomal alleles or additional plasmid-borne alleles that have extended-spectrum β-lactamase (ESBL) activity and/or β-lactamase inhibitor (BLI) resistance activity. In addition, the role of individual mutations/a changes is not completely documented or understood.
View Article and Find Full Text PDFactivity assessment of cefiderocol against Enterobacterales, and spp., including β-lactam nonsusceptible molecularly characterized isolates, collected from 2020 to 2021 in the United States and European hospitals.
Microbiol Spectr
November 2024
JMI Laboratories/Element Iowa City, North Liberty, Iowa, USA.
This study reports the activity of cefiderocol against Enterobacterales, , and spp. isolates collected from the United States and Europe, including Israel and Turkey, from 2020 to 2021. Among Enterobacterales, 2.
View Article and Find Full Text PDFWhole genome sequencing and genotyping multi-drug resistant hospital isolates from Western Kenya.
Access Microbiol
January 2024
Centre for Bioinformatics and Computational Biology, Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.
Objectives: are a frequent cause of nosocomial infections worldwide. Sequence type 147 (ST147) has been reported as a major circulating high-risk lineage in many countries, and appears to be a formidable platform for the dissemination of antimicrobial resistance (AMR) determinants. However, the distribution of this pathogen in Western African hospitals has been scarcely studied.
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