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Evaluation of the inhibitory effect of different molecular weights chitosan on MRGPRX2-mediated mast cell degranulation and the pseudo-allergic reaction.
Immunopharmacol Immunotoxicol
January 2025
Department of Pharmacy, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Objectives: Chitosan is widely used in medicine to regulate immune responses in T cells and dendritic cells. However, research on the regulation of mast cells (MCs) is scarce. Mas-related G-protein-coupled receptor X2 (MRGPRX2) is a key receptor that mediates MC activation.
View Article and Find Full Text PDFUrsolic acid attenuates pseudo-allergic reactions via reducing MRGPRX2-mediated mast cell degranulation.
Immunol Lett
December 2024
Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China. Electronic address:
Mas-related G protein-coupled receptor X2 (MRGPRX2) is a newly identified receptor on mast cells that contribute to IgE-independent pseudo-allergy. Ursolic acid (UA), a pentacyclic triterpenoid, has been reported for its anti-allergy effects. However, the protective mechanism against pseudo-allergic reactions remains unclear.
View Article and Find Full Text PDFDifferential MRGPRX2-dependent activation of human mast cells by polymyxins and octapeptins.
Eur J Pharmacol
December 2024
Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, Victoria, Australia. Electronic address:
Article Synopsis
- The study focuses on the renewed use of polymyxins and their analogues due to the rise of multi-drug resistant Gram-negative bacteria, highlighting differences in their effects on mast cells.
- Clinically used polymyxins can trigger hypersensitivity reactions by activating the MRGPRX2 receptor in mast cells, with octapeptin C4 being particularly potent.
- While polymyxin nonapeptides showed weak effects on mast cells, the findings suggest that understanding these differences could lead to safer polymyxins and better clinical applications of existing drugs.
Nebivolol hydrochloride and its impurities induce pseudo-allergic reactions via mast cell activation.
J Appl Toxicol
February 2025
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Nebivolol hydrochloride is a third-generation β-blocker commonly used to treat cardiovascular diseases. However, it has been reported to induce allergic reactions in clinical use which deserves much attention. Therefore, this study focused on the ability of two isomers of nebivolol and chiral isomer impurities to induce allergic reactions.
View Article and Find Full Text PDFCorydalis yanhusuo extract and its pharmacological substances alleviate food allergy by inhibiting mast cells activation via PLC/PKC/STAT3 pathway.
J Ethnopharmacol
January 2025
School of Pharmacy, Xi'an Jiaotong University, Xi'an, China. Electronic address:
Ethnopharmacological Relevance: Food allergies have increasingly become a disease that affects global health and need for corresponding therapeutic drugs urgently. As a traditional Chinses medicine with a wide range of pharmacological effects, however, there was no clear research confirming therapeutic effect and pharmacological substances of Corydalis yanhusuo (YHS) on food allergies. Mast cells (MCs) are the main effector cells which mediate allergic and pseudo-allergic reactions.
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