A new antifungal 6-substituted 2H-pyran-2-one, named viridepyronone, has been isolated from a cultural filtrate of a strain of Trichoderma viride showing antagonistic activity in vitro toward Sclerotium rolfsii, which is the causal agent of crown and stem rot of artichoke. Viridepyronone was characterized as 6-(4-oxopentyl)-2H-pyran-2-one 2 with spectroscopic methods. Bioassays showed that viridepyronone had a good antifungal activity against S. rolfsii, and its minimum inhibitory concentration (over 90% inhibition) was found to be 196 microg/mL. This is the first report of viridepyronone produced by any species of fungi.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jf034708j | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis, Molecular Docking, and Antimicrobial Evaluation of 2-(Substituted Amino)-N-(6-Substituted-1,3-Benzothiazol-2yl) Acetamide.
Curr Drug Discov Technol
June 2024
Department of Pharmaceutical Chemistry, Pune District Education Association's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412 301, Maharashtra, India.
Background: The development of antimicrobial agents is crucial for several reasons, primarily to combat infectious diseases and to address the growing threat of antimicrobial resistance. The need for the contin-ued development of antimicrobial drugs persists despite the presence of many existing drugs for several reasons viz; emerging new pathogens and diseases, reistance to existing drug and propogation of multi-drug resistance to existing drugs.
Objective: The objective of the study was to synthesize and evaluate the antimicrobial potential of newly synthesized benzothiazole derivatives.
Synthesis, biological evaluation, and In silico molecular docking of N-(4-(4-substitutedphenyl)-6-(substituted aryl) pyrimidin-2-yl)-2-(2-isonicotinoyl hydrazinyl) acetamide.
J Biochem Mol Toxicol
January 2024
Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Ciudad de Mexico, Mexico.
Isonicotinohydrazide is the first-line medication in the prevention and treatment of tuberculosis. Antitubercular, antibacterial, antifungal, antiviral, anti-inflammatory, antimalarial activity, anticancer, antineoplastic activity, and anti-HIV activity are all demonstrated by drugs with a pyrimidine ring. The current study focuses on the synthesis of N-(4-(substituted-phenyl)-6-(substituted-aryl) pyrimidin-2-yl)-2-(2-isonicotinoylhydrazinyl) acetamide from isonicotinohydrazide.
View Article and Find Full Text PDFSynthesis of 2-(6-substituted quinolin-4-yl)-1-alkoxypropan-2-ol as potential antimycobacterial agents.
Chem Zvesti
February 2023
Department of Chemistry, S. P. Mandali's Sir Parashurambhau College (Affiliated to, Savitribai Phule Pune University), Tilak Road, Pune, 411030 India.
Unlabelled: Resistance to antibiotic drugs has directed global health security to a life-threatening situation due to mycobacterial infections. In search of a new potent antimycobacterial, a series of (±) 2-(6-substituted quinolin-4-yl)-1-alkoxypropan-2-ol () have been synthesized. The structures of the newly synthesized derivatives were characterized by spectrometric analysis.
View Article and Find Full Text PDFAntifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs.
Front Cell Infect Microbiol
March 2023
Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, CA, United States.
Fungal infections have become an increasing threat as a result of growing numbers of susceptible hosts and diminishing effectiveness of antifungal drugs due to multi-drug resistance. This reality underscores the need to develop novel drugs with unique mechanisms of action. We recently identified 5-(,-hexamethylene)amiloride (HMA), an inhibitor of human Na/H exchanger isoform 1, as a promising scaffold for antifungal drug development.
View Article and Find Full Text PDFDesign and synthesis of novel -butyphthalide derivatives as promising botanical fungicides.
Z Naturforsch C J Biosci
March 2021
State Key Laboratory of Functions and Applications of Medicinal Plants, College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang550004, PR China.
In order to obtain novel botanical fungicides, three series of novel 6-substituted -butyphthalide derivatives have been designed and synthesized nucleophilic addition, reduction, nitrification, amination, sulfonation, Sandmeyer and Suzuki reaction. The mycelium growth rate method was used to evaluate the inhibition activity against eight phytopathogenic fungi . Preliminary bioassay tests showed that compounds , , , and exhibited better activity for some fungi at 50 μg/mL than the positive drug hymexazol and lead compound -butyphthalide (NBP).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!