IF-liposomes are formed by a unique process that involves fusing small liposomes into interdigitated lipid sheets, using either ethanol or hydrostatic pressure. The interdigitation-fusion method requires liposome formulations with lipids that form the L beta I phase. Preparing ethanol-induced IF-liposomes is simple and quick. IF-liposomes are particularly well suited for biomembrane research experiments that require large unilamellar liposomes and for liposome drug delivery applications that require a high drug-to-lipid ratio.
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Inside-outside self-assembly of light-activated fast-release liposomes.
Phys Chem Chem Phys
June 2015
Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.
Building additional functionality into both the membrane and the internal compartments of biocompatible liposomes by self-assembly can provide ways of enhancing colloidal stability and spatial and temporal control of contents release. An interdigitation-fusion process is used to encapsulate near infrared light absorbing copper sulfide nanoparticles in the interior compartments of dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol liposomes. Once formed, the liposome membrane is modified to include lysolipids and polyethylene glycol lipids by partitioning from lysolipid and PEG-lipid micelles in solution.
View Article and Find Full Text PDFInterdigitation--fusion liposomes.
Methods Enzymol
December 2003
Bio Delivery Sciences International, Inc., UMDNJ-New Jersey Medical School, 185 South Orange Avenue, ADMC4 Newark, New Jersey 07103, USA.
IF-liposomes are formed by a unique process that involves fusing small liposomes into interdigitated lipid sheets, using either ethanol or hydrostatic pressure. The interdigitation-fusion method requires liposome formulations with lipids that form the L beta I phase. Preparing ethanol-induced IF-liposomes is simple and quick.
View Article and Find Full Text PDFStreptokinase entrapment in interdigitation-fusion liposomes improves thrombolysis in an experimental rabbit model.
Thromb Haemost
June 1997
Liposome Company, Inc., Princeton, NJ 08540, USA.
The successful design of new thrombolytic agents depends on providing these agents with increased clot selectivity. As recently demonstrated (10), entrapment of tissue plasminogen activator into liposomes apparently provided the selective targeting needed to improve the efficacy of this fibrinolytic agent. To test whether liposomal entrapment would benefit streptokinase, a fibrinolytic agent with a different mode of action and inactivation, we compared liposomal streptokinase with free streptokinase in an experimental rabbit model of thrombolysis.
View Article and Find Full Text PDFContrast material-carrying liposomes: biodistribution, clearance, and imaging characteristics.
Radiology
March 1995
Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115.
Purpose: To assess the biodistribution, clearance, and computed tomographic (CT) imaging characteristics of interdigitation-fusion (IF) liposomes that carry iotrolan in their aqueous phases.
Materials And Methods: Biodistribution and clearance of liposomes containing iotrolan produced with the IF method (IF vesicles) were assessed in rats. CT scans of rats and dogs were obtained after injection of IF vesicles at 100 and 250 mg of iodine per kilogram of body weight.
Interdigitation-fusion: a new method for producing lipid vesicles of high internal volume.
Biochim Biophys Acta
November 1994
Liposome Company, Inc., Princeton, NJ 08540.
Previously we demonstrated that fused phospholipid sheets can be formed from small unilamellar vesicles (SUVs) comprised of saturated symmetric chain lipids by exposing them to concentrations of ethanol sufficient to cause bilayer interdigitation (Boni et al. (1993) Biochim. Biophys.
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