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Insights into the paradoxical effect of smoking on vasculitis: a comprehensive review.
Sarcoidosis Vasc Diffuse Lung Dis
December 2024
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Vasculitis is a group of uncommon diseases characterized by inflammation of blood vessels, which contributes to the organ ischemia and damage. Cigarette smoke contains a high concentration of various toxins, which have the potential to affect the immune response and development of autoimmune/autoinflammatory rheumatic diseases including vasculitis. Smoking influences both innate and adaptive immune systems and plays binary functions in modulating immunity by either aggravating pathogenic immune responses or attenuating defensive immunity.
View Article and Find Full Text PDFNecrobiotic Pulmonary Nodules in Ulcerative Colitis: A Rare Case Report.
Am J Case Rep
December 2024
Division of Thoracic Surgery, Imperial College NHS Healthcare Trust and National Heart and Lung Institute, London, United Kingdom.
BACKGROUND Necrobiotic pulmonary nodules represent an exceptionally rare extraintestinal manifestation of inflammatory bowel disease (IBD), comprising conditions such as Crohn's disease and ulcerative colitis. These nodules pose significant diagnostic challenges, often mimicking autoimmune pathologies like sarcoidosis, rheumatoid arthritis, and other granulomatous diseases, thereby complicating the clinical management of affected patients. The rarity and nonspecific clinical presentation of necrobiotic pulmonary nodules necessitate a reliance on a combination of radiological and histological findings for accurate diagnosis.
View Article and Find Full Text PDFPatterns and Outcomes of Pediatric Uveitis in a University-Based Tertiary Referral Center in Riyadh, Saudi Arabia.
Ocul Immunol Inflamm
December 2024
Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Article Synopsis
- The study aimed to analyze the patterns and outcomes of uveitis in children through a retrospective patient review.
- A total of 184 pediatric patients were examined, revealing that panuveitis was the most common type, with a significant number displaying non-granulomatous and non-infectious uveitis.
- After one year, most patients (85.4%) had improved vision, achieving at least 20/40 visual acuity, and Vogt-Koyanagi-Harada disease was identified as the most prevalent specific diagnosis.
Inflammatory Mesenteric Disease and Sarcoidosis-like Reaction in a Patient with Lung Adenocarcinoma Who Received Pembrolizumab: Paraneoplastic Syndrome, Secondary to Checkpoint Inhibitor or Chance Finding?
Curr Oncol
November 2024
Medical Oncology Department, University Hospital of Salamanca, 37007 Salamanca, Spain.
: Anti PD1/PD-L1 agents, including pembrolizumab, have revolutionized the oncological treatment of different types of cancer, including non-small cell lung cancer. The most frequent complications associated with this type of treatment are mild and are located at the thyroid, pulmonary or hepatic level. Sarcoid like reaction and mesenteric panniculitis secondary to pembrolizumab treatment are two very rare adverse effects.
View Article and Find Full Text PDFThe association between physical trauma and autoimmune articular and dermatological disorders.
Autoimmun Rev
January 2025
Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. Electronic address:
Objective: This review investigates the association between physical trauma and the onset and progression of various inflammatory diseases, including psoriatic arthritis (PsA), rheumatoid arthritis (RA), spondyloarthropathies (SpA), and Familial Mediterranean Fever (FMF). In addition, we will refer to the linkage between physical injury and skin manifestations in patients with psoriasis, sarcoidosis and systemic sclerosis. The aim is to summarize the current evidence and explore the potential mechanisms through which trauma may affect these conditions.
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