Objectives: To analyze the clinical features of uncinate process carcinoma of the pancreas and to improve the resection rate.
Methods: From January 1990 to June 1999, 10 patients with pancreas uncinate process carcinoma received Whipple's operation. Portal vein (PV) resection and reanastomosis were performed in 5 patients, and the resected length varied from 2.0 to 4.2 cm. Two patients underwent PV lateral wall partial resection.
Results: Among the 7 patients undergoing PV resection, 1 died of hepatic failure 3 days after operation. One patient suffered from postoperative chylous ascites. These 6 patients survived 13 to 29 months postoperatively. Among the 3 patients without PV resection, 2 survived 13 months and 14 months respectively. One patient was alive by the end of follow-up for 11.5 months postoperatively.
Conclusion: Although uncinate process carcinoma of the pancreas has a tendency to invade the adjacent PV and superior mesentery vein, it should not be simply regarded as a contraindication of radical resection.
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Background: Right temporal variant frontotemporal dementia (rtvFTD), a new recognized entity among the FTD-spectrum, is characterized by right anterior temporal lobe (rATL) atrophy and a peculiar clinical presentation, involving face and emotions recognition, memory, and naming deficits and behavioral disturbances. Clinical diagnosis is challenging, since rtvFTD shares features with both the behavioral variant FTD (bvFTD) and the semantic variant primary progressive aphasia (svPPA), and there is no consensus yet on its designation and characterization. Although rATL neurodegeneration is a hallmark of this syndrome, only a few studies investigated patterns of gray matter (GM) atrophy.
View Article and Find Full Text PDFBackground: Neuritic plaques with fibrillar beta-amyloid (Aβ) peptides and tau-protein neurofibrillary tangles, hallmark features of Alzheimer's disease (AD) pathology, have been concomitantly associated with white matter (WM) integrity loss, while a unique effect of each pathology on WM integrity in a more demographically diverse population remains unknown.
Method: To examine the degree to which each pathology affects WM integrity in a more diverse non-demented cohort, Aβ and tau PET, diffusion-weighted imaging (DWI), and cognition (memory and executive function composites) were examined from the U.S.
Alzheimers Dement
December 2024
Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montréal, QC, Canada.
Background: The presence of cortical amyloid-beta pathology is associated with white matter microstructural changes in Alzheimer's disease (AD), especially in tracts associated with memory. However, the relationships between tract-specific neuroinflammation and plasma markers of astrogliosis is underexamined; similarly, the involvement of tau neurofibrillary tangles is unclear in neuroinflammation. Here, we investigated the association between plasma glial fibrillary acidic protein (GFAP) and changing proportion of intravoxel freewater-a microstructural change associated with neuroinflammation-within white matter tracts vulnerable to AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Brown University, Providence, RI, USA.
Background: Neuritic plaques with fibrillar beta-amyloid (Aß) peptides and tau-protein neurofibrillary tangles, hallmark features of Alzheimer's disease (AD) pathology, have been concomitantly associated with white matter (WM) integrity loss, while a unique effect of each pathology on WM integrity in a more demographically diverse population remains unknown.
Method: To examine the degree to which each pathology affects WM integrity in a more diverse non-demented cohort, Aß and tau PET, diffusion-weighted imaging (DWI), and cognition (memory and executive function composites) were examined from the U.S.
Inflammation
January 2025
Department of Otorhinolaryngology, Dankook University College of Medicine, 201 Manghyang-Ro, Dongnam-Gu, Cheonan, 31116, Republic of Korea.
During nasal polyp (NP) development, activated T cells differentiate into T helper (Th) 1, Th2, and Th17 cells. Additionally, regulatory T cells (Tregs) that have an immune suppressive function are involved in the pathophysiology of chronic rhinosinusitis (CRS) with NP (CRSwNP). Tregs can act as effector cells that produce inflammatory cytokines, such as interleukin (IL)-17A.
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