This study presents a patient (JH) suffering from acquired deep dyslexia. According to a cognitive model of reading, JH exhibited a significant impairment in both the phonological and lexical routes to reading. A rehabilitation program was proposed. We decided to focus on the lexical route using a priming paradigm. The written words were associated with a picture and the patient was invited to construct a mental association between the written word and the image. During five sessions, JH was trained to read 50 words. A pre-test, a post-test, and an 8-month follow-up session consisted of reading 140 written words including the 50 trained words. At the post-test, 90% of the trained words were accurately read. At the follow-up session, JH's reading performance for the trained words was still highly accurate at 84%. This strong effect is discussed and ways of increasing the patient's abilities to read are proposed.
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Brief Bioinform
November 2024
Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, No. 97 Buxin Road, Dapeng New District, Shenzhen 518124, China.
Identifying the regulatory effects of noncoding variants presents a significant challenge. Recently, the accumulation of epigenomic profiling data in wheat has provided an opportunity to model the functional impacts of these variants. In this study, we introduce Language of Genome for Wheat (LOGOWheat), a deep learning-based tool designed to predict the regulatory effects of noncoding variants in wheat.
View Article and Find Full Text PDFBrain
January 2025
Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Acoustic-phonetic perception refers to the ability to perceive and discriminate between speech sounds. Acquired impairment of acoustic-phonetic perception is known historically as "pure word deafness" and typically follows bilateral lesions of the cortical auditory system. The extent to which this deficit occurs after unilateral left hemisphere damage and the critical left hemisphere areas involved are not well defined.
View Article and Find Full Text PDFNat Commun
January 2025
Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan.
Genomic variants causing abnormal splicing play important roles in genetic disorders and cancer development. Among them, variants that cause the formation of novel splice-sites (splice-site creating variants, SSCVs) are particularly difficult to identify and often overlooked in genomic studies. Additionally, these SSCVs are frequently considered promising candidates for treatment with splice-switching antisense oligonucleotides (ASOs).
View Article and Find Full Text PDFActa Anaesthesiol Scand
February 2025
Department of Brain and Spinal Cord Injury, Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Background: The harm-benefit balance for early out-of-bed mobilisation of patients with severe acquired brain injury (ABI) in neurointensive care units (neuro-ICUs) is unclear, and there are no clinical guidelines. This study aimed to survey the current clinical practice and perceptions among clinicians involved in first out-of-bed mobilisation in Scandinavian neuro-ICUs.
Methods: This was a cross-sectional, anonymous, web-based survey; the reporting follows the recommended CROSS checklist.
J Plast Reconstr Aesthet Surg
February 2024
Plastic Surgery Department, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK. Electronic address:
Background: Autologous breast reconstruction patients require thorough assessment, with the profunda femoris artery perforator (PAP) flap having become an important autologous reconstruction option alongside the deep inferior epigastric perforator (DIEP) flap. Breast reconstruction impacts patients psychologically, physically and mentally. The BREAST-Q aids in the assessment of patient-reported outcome measures (PROMs).
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