AI Article Synopsis
- An aggressive surgical approach for advanced gallbladder carcinoma was studied to see if it improves survival rates.
- The study involved 59 patients divided into three groups: those who underwent surgery, those who received chemotherapy, and those who received no significant treatment.
- Results showed that patients who had surgery without distant metastasis had better outcomes compared to those who had chemotherapy or surgery with metastasis, suggesting radical surgery is best for non-metastatic cases and that chemotherapy is an alternative for metastatic ones.
Article Abstract
Background/purpose: An aggressive approach is required to resect advanced carcinoma of the gallbladder. Therefore, an extended surgical procedure often brings about a poor surgical outcome. To test whether an aggressive surgical treatment can improve the survival rate for primary advanced carcinoma of the gallbladder, 59 patients with stage IV primary gallbladder carcinoma were studied.
Methods: Patients were divided into three treatment groups for the survival analysis: group A (resectional surgery, n = 29), group B (low-dose cis-diamminedichloroplatinum-II and 5-fluorouracil therapy, n = 10), and group C (exploratory laparotomy, other treatment modalities, or no treatment, n = 20).
Results: The prognosis of group A patients was significantly better than that of group B (P = 0.018) or group C (P = 0.0009). Furthermore, group A patients were divided into subgroups. The prognosis of patients resected with no distant metastasis (group A1) was significantly better than that of patients resected with distant metastases of the distant lymph nodes and the liver (group A2) (P = 0.0004). Also, there was no significant difference in the survival rate between the patients resected with distant metastasis (group A2) and chemotherapy cases (group B).
Conclusions: These results indicated that radical surgery should be performed for patients with no distant metastasis, and that chemotherapy might be a useful alternative treatment for patients with distant metastasis in advanced carcinoma of the gallbladder.
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| http://dx.doi.org/10.1007/s00534-003-0848-5 | DOI Listing |
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