The present work discusses the characteristics of solvation (Gibbs energy, enthalpic and entropic terms of Gibbs energy) for ketoprofen together with other nonsteroidal antiinflammatory drugs (NSAIDs) in aliphatic alcohols. Ketoprofen was studied by classical thermoanalytical methods of sublimation calorimetry, solution calorimetry, and solubility. Temperature dependence of the saturated vapor pressure was determined, and the sublimation enthalpy, delta H(sub) (0) and sublimation entropy, delta S(sub)(0), as well as their respective relative fractions in the total process were calculated. The parameters yielded for ketoprofen were compared with the respective literature data of other benzophenone derivatives. The Gibbs energy of solvation as well as enthalpic and entropic terms thereof in aliphatic alcohols were also studied for ketoprofen and compared with the properties of model substances and other NSAIDs (benzoic acid, diflunisal, flurbiprofen, and naproxen). In all cases, the major driving force of the solvation process is enthalpy. Correlations were derived between Gibbs energy of solvation in octanol, delta G(solv)(oct), and the transfer Gibbs energy from water to octanol, delta G(tr)(0).
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