Background: The aim of the study was an estimation of the relation between the gallbladder (GB) motility function and the presence and quantity of enterogastric reflux (EGR).
Material And Methods: We investigated 172 patients: 90 with physiological GB function (filling and emptying) (FGB), 21 with impaired GB function (prolonged filling and ejection fraction < 45%) and 61 with afunctional gallbladder (AGB) (without visualisation). The study was performed during 90 min (1 f/min) after i.v. application of 185 MBq 99m Tc-dietil IDA. After 30 min, a test meal was given while at the end the stomach was marked. According to the parameters from time activity curves over the stomach and hepatobiliary system, the index of EGR was calculated, while GB filling and ejection fraction were estimated from the GB time/activity curve.
Results: Most frequently, EGR occurs in AGB (47.5%), followed by IGB (43%) and FGB (41%), without significant differences (p > 0.05). The significantly (p < 0.05) highest value of EGR was obtained in the patients with AGB in comparison to IGB and FGB. EGR values were in correlation (r = 0.168, p < 0.05) with the functional status of the GB. In the patients with pathological values of EGR (> 10%), significantly higher values (p < 0.05) are obtained in AGB than in IGB and FGB. Also, these values were in correlation with the functional status of the GB (r = 0.284, p < 0.05).
Conclusions: We can conclude that EGR occurs more frequently in the patients with afunctional GB in comparison with those with functional and decreased motor function. Also, EGR quantity is in correlation with the impairment of the GB function.
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Vet Sci
December 2024
Gastrovet, São Paulo 04077003, Brazil.
Gallbladder mucocele, cholelithiasis, choledocholithiasis, and cholecystitis are significant contributors to morbidity and mortality in dogs. The exact etiology of these conditions remains poorly understood, though various factors, such as endocrinopathies, dyslipidemia, and impaired gallbladder motility, have been suggested as potential contributors. Surgical intervention has been described as the first choice of treatment when biliary rupture or obstruction is suspected; however, medical management may be an important part of therapeutic or preventative strategy.
View Article and Find Full Text PDFBioengineering (Basel)
January 2025
Department of Ultrasound, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Background: Cholesterol gallstone disease (CGS) is often accompanied by gallbladder contraction dysfunction and chronic inflammation, but effective therapeutic options remain limited. This study investigates whether a low-intensity pulsed ultrasound (LIPUS) treatment can improve gallbladder motility and alleviate chronic inflammation while exploring the underlying mechanisms.
Methods: Gallbladder motility was assessed through in vitro and in vivo contraction tests, while bile condition was evaluated by observing bile crystal clearance.
Chem Biol Drug Des
January 2025
Department of Hepato-Biliary-Pancreatic Surgery, Shaoxing People's Hospital, Shaoxing, People's Republic of China.
Gallbladder cancer is the most prevalent malignancy of the biliary tract and has a dismal overall survival even in the present day. The development of new drugs holds promise for improving the prognosis of this lethal disease. The possible anti-neoplastic role of morusin was investigated both in vitro and in vivo.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of Gastroenterology & Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Pancreatic cancer is associated with high rates of morbidity and mortality. Endoscopic ultrasound (EUS)-guided biopsy has become the standard diagnostic modality per the guidelines. The use of EUS has been growing for providing various treatments in patients with pancreatic cancers: biliary and gallbladder drainage for those with malignant biliary obstruction, gastroenterostomy for malignant gastric outlet obstruction, celiac plexus/ganglia neurolysis for pain control, radiofrequency ablation, placement of fiducial markers, and injection of local chemotherapeutic agents.
View Article and Find Full Text PDFNat Cell Biol
January 2025
State Key laboratory of Genetic Engineering, School of Life Sciences, Liver Cancer Institute of Zhongshan Hospital, Fudan University, Shanghai, China.
Severe damage to the intrahepatic biliary duct (IHBD) network occurs in multiple human advanced cholangiopathies, such as primary sclerosing cholangitis, biliary atresia and end-stage primary biliary cholangitis. Whether and how a severely damaged IHBD network could reconstruct has remained unclear. Here we show that, although the gallbladder is not directly connected to the IHBD, there is a common hepatic duct (CHD) in between, and severe damage to the IHBD network induces migration of gallbladder smooth muscle cells (SMCs) to coat the CHD in mouse and zebrafish models.
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