To evaluate content of interleukines (IL-1, IL-2, IL-4 and IL-6) and tumor necrosis factor (TNF) in patients with chronic hepatitis C (CHC), 72 CHC patients (37 males and 35 females, mean age 37.2 +/- 4.8 years) were examined. The control group consisted of 20 healthy donors (mean age 25.5 +/- 2.3 years). It was found that low levels of IL-1, IL-2, IL-6, TNF evidence for weak immune response which means long-term virus circulation and active replication. The highest concentrations of the above cytokines correspond to low replicative activity while high IL-4 levels point to active virus replication. IL-1, IL-2, IL-4, IL-6, TNF were high in patients with high cytolysis. Cytokine regulation of immune response can be used for assessment of the effectiveness of antiviral and immunocorrective therapy.
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