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Article Synopsis
- Clinical events can occur after percutaneous coronary intervention (PCI), especially in complex cases, and using advanced intracoronary imaging and pressure guidewires may help reduce these risks.
- The OPTI-XIENCE study is an international, multicenter prospective observational study involving 1,064 patients with specific high-risk characteristics undergoing stent implantation, monitoring them for 12 months.
- The study aims to evaluate the effectiveness of using these intracoronary tools, with the primary focus on the rate of target lesion failure after one year, while also assessing additional cardiovascular outcomes.
The Contemporary Use of Intracoronary Brachytherapy for In-Stent Restenosis: A Review.
Cardiovasc Revasc Med
June 2023
Department of Internal Medicine, University of Kentucky, Lexington, KY, United States of America.
In-stent restenosis (ISR) has been a major limitation in interventional cardiology and constitutes nearly 10 % of all percutaneous coronary interventions in the United States. Drug-eluting stent (DES) restenosis proves particularly difficult to manage and poses a high risk of recurrence and repeat intervention. Intra-coronary brachytherapy (IBT) has been traditionally viewed as a potential treatment modality for ISR.
View Article and Find Full Text PDFSevere Coronary Artery Vasospasm after Mitral Valve Replacement in a Diabetic Patient with Previous Stent Implantation: A Case Report.
J Crit Care Med (Targu Mures)
April 2022
George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Targu Mures, Romania.
Postoperative coronary vasospasm is a well-known cause of angina that may lead to myocardial infarction if not treated promptly. We report a case of a 70-year-old female with severe mitral regurgitation submitted to mitral valve replacement, and a history of diabetes mellitus type II, stroke, idiopathic thrombocytopenic purpura on steroid therapy, and previous percutaneous coronary intervention (PCI) for severe obstruction of the circumflex coronary artery, 4 months prior to surgery. Immediately after intensive care unit admission, the patient developed pulseless electrical activity which required extracorporeal membrane oxygenation for hemodynamic support.
View Article and Find Full Text PDFIn Stent Neo-Atherosclerosis: Pathophysiology, Clinical Implications, Prevention, and Therapeutic Approaches.
Life (Basel)
March 2022
Cardiology, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
Article Synopsis
- - Despite advancements in revascularization therapies, many patients receiving percutaneous coronary intervention (PCI) experience complications like stent failure due to neo-atherosclerosis (NA), which can lead to serious outcomes such as late in-stent restenosis and stent thrombosis.
- - Drug-eluting stents can further complicate healing due to anti-proliferative agents that delay vascular repair, heightening the risk of NA and its associated issues.
- - The review discusses the need for early detection of NA using advanced intra-coronary imaging methods and explores various prevention and treatment strategies, including tailored medications and innovative invasive approaches.
Angiography-derived physiology guidance vs usual care in an All-comers PCI population treated with the healing-targeted supreme stent and Ticagrelor monotherapy: PIONEER IV trial design.
Am Heart J
April 2022
Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland.
Article Synopsis
- * This trial will involve 2,540 participants randomized to receive either PCI guided by QFR or standard care, utilizing a specific stent that allows for shorter anti-clotting therapy post-procedure.
- * The primary goal is to see if QFR-guided PCI is as effective as usual care in preventing major cardiac events within one year, with follow-ups lasting up to three years.
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