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Unraveling the role of autophagy regulation in Crohn's disease: from genetic mechanisms to potential therapeutics.
Adv Biotechnol (Singap)
March 2024
Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
Autophagy serves as the primary intracellular degradation mechanism in which damaged organelles and self-cytoplasmic proteins are transported to the lysosome for degradation. Crohn's disease, an idiopathic chronic inflammatory disorder of the gastrointestinal tract, manifests in diverse regions of the digestive system. Recent research suggests that autophagy modulation may be a new avenue for treating Crohn's disease, and several promising small-molecule modulators of autophagy have been reported as therapeutic options.
View Article and Find Full Text PDFFunctional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues.
Inflamm Res
January 2025
Department of Biochemistry, Cancer Biology, Neuroscience, and Pharmacology, School of Medicine, Meharry Medical College, 1005 D.B. Todd Jr. Blvd, Nashville, TN, USA.
Background: The aberrant expression of α defensin 5 (DEFA5) protein in colonic inflammatory bowel diseases (IBDs) underlies the distinct pathogenesis of Crohn's colitis (CC). It can serve as a biomarker for differentiating CC from Ulcerative colitis (UC), particularly in Indeterminate colitis (IC) cases into UC and CC. We evaluated the specificity of commercially available anti-DEFA5 antibodies, emphasizing the need to further validate their appropriateness for a given application and highlighting the necessity for novel antibodies.
View Article and Find Full Text PDF[An update on surgical treatment options for inflammatory bowel disease].
Inn Med (Heidelb)
January 2025
Klinik für Allgemein‑, Viszeral- und Thoraxchirurgie, Klinikum Darmstadt GmbH, Grafenstraße 9, 64283, Darmstadt, Deutschland.
There are national and international guidelines and developments for the surgery of chronic inflammatory bowel disease (IBD) that contribute to better patient care. Important recommendations include increasingly individualized and minimally invasive approaches with the integration of new technologies. The indication for abdominal surgery remains tied to specialization, not least in order to continue to be able to assess the importance of sequential treatment and multimodality in improving surgical results and minimizing risks.
View Article and Find Full Text PDFSleep Deficiency and Fatigue in Adults with Inflammatory Bowel Disease: A Systematic Review.
West J Nurs Res
January 2025
University of Connecticut, Storrs, CT, USA.
Purpose: Fatigue is one of the most common and disabling symptoms experienced by people with inflammatory bowel disease; however, interventions to treat fatigue are limited. The purpose of this systematic review is to examine the relationship between sleep deficiency and fatigue in adults with inflammatory bowel disease and to describe the demographic and clinical factors associated with fatigue to inform future intervention work.
Methods: We conducted a systematic review and reported the results using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Management of Anal Fistula with Crohn's Disease.
J Anus Rectum Colon
January 2025
Inflammatory Bowel Disease Center, Coloproctology Center Takano Hospital, Kumamoto, Japan.
Crohn's disease (CD) causes gastrointestinal symptoms (i.e., diarrhea and abdominal pain), systemic symptoms (i.
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