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| http://dx.doi.org/10.1177/014107680309601113 | DOI Listing |
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Reconstructed human keloid models show heterogeneity within keloid scars.
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Department of Molecular Cell Biology and Immunology, O|2 Lab Building, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Keloid scars are often described as having an actively growing peripheral margin with a regressing centre. The aim of this study was to examine the possible heterogeneity within keloids and the involvement of different regions within and around keloid scars in the pathogenesis, using an in vitro keloid scar model. In vitro skin models were constructed from keratinocytes and fibroblasts from normal skin and different regions within and around keloid scars: periphery, centre, and (adjacent) surrounding-normal-skin regions.
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Keloid scarring of the distal upper extremity is very rare. We report a Caucasian woman who presented with aggressive keloids of the hand and wrist causing De Quervain's syndrome, superficial radial-nerve entrapment and ulnar-nerve compression at the wrist. Multiple operations were required to alleviate her symptoms.
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