AI Article Synopsis
- - The study aimed to evaluate how common vitamin B12 deficiency is in patients who do not have atrophic gastric mucosa, and to explore any links with demographic and health factors.
- - Out of 310 patients examined, a significant proportion showed low vitamin B12 levels, with 67.4% below 250 pg/mL; factors like age and H. pylori infection were found to significantly influence vitamin B12 deficiency.
- - The findings suggest that higher rates of vitamin B12 deficiency may be connected to H. pylori, and aging is a crucial risk factor, while traditional hematologic measures were not reliable indicators of deficiency.
Article Abstract
Background/aims: The aim of this study was to assess the frequency of vitamin B12 deficiency in patients with non atrophic gastric mucosa and any relationship between the presence of vitamin B12 deficiency and demographic, hematologic, and histopathologic parameters.
Methods: Three hundred and ten patients with no gastric mucosal atrophy on histologic evaluation were included in the study. Chronic inflammation, neutrophil activity and H. pylori load were scored using the Sydney classification system. Variables that might influence or predict the presence of vitamin B12 deficiency (age, gender, hemoglobin, mean corpuscular volume, serum folate level, scores of histologic parameters) were evaluated by univariate/multivariate analysis.
Results: The percentages of patients with vitamin B12 concentrations of < 250 pg/mL, < 200 pg/mL, and =100 pg/mL were 67.4%, 46.8% and 6.5% respectively. Patient age and all three histologic were inversely related to vitamin B12 deficiency (p<0.05). By multivariate analysis, factors independently associated with serum vitamin B12 deficiency were age and antral H. pylori load (p<0.05).
Conclusions: The higher frequency of vitamin B12 deficiency in this study compared with a western study may be a reflection of the effect of H. pylori infection on serum vitamin B12 level. In addition, age was shown to be an independent risk factor for vitamin B12 deficiency irrespective of gastric atrophy. It is already known that the presence of H. pylori on gastric mucosa influence serum vitamin B12 levels. Hematologic parameters are not useful in predicting the deficiency of this vitamin.
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