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| http://dx.doi.org/10.1136/bmj.327.7422.1038 | DOI Listing |
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Cadmium alters the cellular metabolome of human ovarian granulosa cells.
Toxicol Appl Pharmacol
December 2024
Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Department of Reproductive Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China. Electronic address:
Article Synopsis
- Cadmium (Cd) is a toxic heavy metal that negatively affects ovarian folliculogenesis, particularly damaging granulosa cells, essential for follicular development.
- In an experiment, human granulosa cells (KGN cells) were exposed to varying levels of Cd (3 and 10 μM), resulting in a dose-dependent decrease in cell viability and a significant alteration in metabolism, with hundreds of metabolites showing differential expression.
- The study revealed enrichment in various metabolic pathways, including nucleotide and sphingolipid metabolism, providing insights into how Cd exposure damages granulosa cells and contributing to the understanding of its ovarian toxicity.
Analysis of -Mediated Network in Regulating Fertility Restoration in .
Int J Mol Sci
November 2024
Institute of Vegetable Crops, Jiangsu Academy of Agricultural Sciences, Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement, Nanjing 210014, China.
Ogura cytoplasmic male sterility (CMS) lines play a crucial role in the utilization of heterosis. However, valuable traits, such as disease resistance genes from Ogura CMS hybrids, are challenging to incorporate for germplasm innovation, particularly in cabbage and broccoli. To date, the -mediated network regulating fertility restoration remains largely unexplored.
View Article and Find Full Text PDFBPA-free? Exploring the reproductive toxicity of BPA substitutes BPS and BPF on endometrial decidualization.
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Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China; Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei 430071, China; Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan, Hubei 430071, China. Electronic address:
Bisphenol A (BPA) exposure is linked to multiple adverse health outcomes, prompting the rise of "BPA-free" products. However, substitutes like Bisphenol S (BPS) and Bisphenol F (BPF) are equally prevalent, with detection frequencies and concentrations rivaling BPA. Our research previously identified BPA as an endocrine disruptor affecting reproductive and developmental systems.
View Article and Find Full Text PDFseed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A.
Food Sci Nutr
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Department of Biochemistry, Faculty of Biomedical Sciences Kampala International University Bushenyi Uganda.
Article Synopsis
- - This study explores the impact of Bisphenol A (BPA), an endocrine disruptor known to affect male fertility, on the testicular mitochondria of male albino rats and tests the protective effects of seed oil (CMSO).
- - Six groups of rats were used, with varying doses of BPA and CMSO; the study measured mitochondrial enzyme activity, membrane potential, protein levels, and body weight post-exposure.
- - Results showed that BPA reduced key mitochondrial activities and rat body weight, but coadministration of CMSO helped restore these disrupted functions, suggesting CMSO could be a potential treatment for toxins like BPA.
Trends and Regional Differences for Fertility Preservation Procedures in Women With Breast Cancer.
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September 2024
Innovation Institute for Fertility Preservation, Yorkvillle, NY and New Heaven, CT; Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT. Electronic address:
Article Synopsis
- Breast cancer is the most common cancer in women of reproductive age, and chemotherapy often leads to the need for fertility preservation (FP), with established methods like embryo, oocyte, or ovarian tissue cryopreservation available.
- A study involving 1623 women from multiple countries showed a consistent increase in FP referrals, with 38.7% of referred women undergoing FP, particularly oocyte cryopreservation, which became more popular over the years.
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